Chaperone “Saves” Tau, Turning it into Toxic Oligomers
As heat shock protein and co-chaperone team up to shield tau from degradation, they create toxic oligomers.
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As heat shock protein and co-chaperone team up to shield tau from degradation, they create toxic oligomers.
New research connects extracellular Aβ to intracellular kinases that mediate its toxicity.
Older people improved memory and attention after playing a challenging video game, supporting the idea that multitasking could have benefits for cognition.
New imaging data suggests degeneration of the fornix could help identify seniors on the verge of cognitive decline.
A new study supports the idea that non-motor symptoms of Parkinson's disease may aid earlier diagnosis.
Amyloid fibrils seeded by Alzheimer’s brain extracts indicate that Aβ forms specific strains in different individuals.
Cerebrospinal Fluid Tau Climbs in Aβ Mouse Models Coverage Denial For Amyloid Scans Riles Alzheimer’s Community Pooled GWAS Reveals New Alzheimer’s Genes and Pathways Are Subtle Memory Concerns a Sign of Future Dementia? Clinical Trials Roundup: Four Hits
Tau, α-Synuclein Spread: Crazy Stuff—How Might It Work? Like Star Born of Supernova, Plaque Born of Exploded Neuron? Can Dousing PyroGlu-Aβ Treat Alzheimer’s Disease? Field Ramps Up "Mini" Mouse MRI LRRK Watchers’ Eyes Turn to Inflammation, Auto
Solanezumab Selected for Alzheimer’s A4 Prevention Trial HAI—Spotlight on Tau Tracers at Human Amyloid Imaging Meeting HAI—Amyloid Imaging in the Clinic: New Guidelines and Data HAI—Sharper Curves: Revamping a Biomarker Staging Model HAI—Standardizing Amy
A deletion in chromosome 22 points to new genetic risk factors for Parkinson's disease.
FUS, a protein tied to neurodegeneration, normally mends DNA breaks, according to a paper in Nature Neuroscience.
It's not just for neurodevelopment anymore. Death receptor 6—known for pruning axons—also trims unused connections in adulthood, hinting at a function in Alzheimer's.
Proposed preclinical stages for Alzheimer’s disease predict well who is most likely to progress to Alzheimer’s dementia.
What’s better for future treatment of Parkinson’s: patient-derived or banked iPSCs? In comparison, patient’s own come out on top.
A new RNA interference therapy for amyotrophic lateral sclerosis has some success in mice and monkeys.