HAI—Aβ: First in Alzheimer’s Cascade, or Just Another Player?
Scientists worldwide now perform amyloid imaging on scores of research participants to figure out how Aβ buildup relates to other markers of neurodegeneration...
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New Assays for Aβ Oligomers—Spinal Fluid a Miss, Brain Awash
Like a blue moon, could oligomeric amyloid-β in the cerebrospinal fluid (CSF) be too rare to be informative?...
Truncated Tau Triggers Tangles, Transmits Pathology
What transforms tau from a well-behaved protein into a rogue?...
No Hill of Beans: AlzRisk Adds Obesity, Expands Diabetes
Did you ever wonder what all the studies on weight and Alzheimer’s amount to at the end of the day?...
HAI—Standardizing Amyloid PET: The Centiloid Project
A centiloid is a proposed unit of measure on a unified scale for all amyloid-β imaging tracers used in positron emission tomography (PET)...
HAI—Sharper Curves: Revamping a Biomarker Staging Model
Clifford Jack's hypothetical model showing biomarkers emerging at different stages of AD surged to the top of the Most-Popular-Slide-at-Conferences chart...
Not So Fast: Amyloid PET Needs More Data Before Insurance Pays
Your health insurance may not cover brain amyloid scans anytime soon...
C9ORF72 Function: Is the ALS Protein a Membrane Traffic Cop?
C9ORF72, made by the ALS-linked gene of the same name, finally has a job description: According to two recent studies, it regulates membrane trafficking...
HAI—Amyloid Imaging in the Clinic: New Guidelines and Data
Since the FDA approved the Aβ imaging agent florbetapir (Amyvid®) last April, academics and doctors have debated how it should be used...
Potamkin Prize Honors Work in Prevention, Biomarkers
The 2013 Potamkin Prize for Research in Pick’s, Alzheimer’s, and Related Diseases will go to three neurologists who have helped advance human longitudinal studies of AD...
Human Amyloid Imaging 2013
Solanezumab Selected for Alzheimer’s A4 Prevention Trial HAI—Spotlight on Tau Tracers at Human Amyloid Imaging Meeting HAI—Amyloid Imaging in the Clinic: New Guidelines and Data HAI—Sharper Curves: Revamping a Biomarker Staging Model HAI—Standardizing Amy
One Protein Fits All? Non-AD Epilepsy Models Thrive Sans Tau
The results of a study extend the benefits of reducing the protein to mouse and fly epilepsy models whose Aβ levels and cognition are normal...
Low Calcium Jams Neuron-Muscle Communication in ALS Fish
A dearth of calcium appears to silence nerves attempting to communicate with muscles in a zebrafish model expressing a mutant version of the ALS gene TDP-43...
HAI—Spotlight on Tau Tracers at Human Amyloid Imaging Meeting
A group of 250 scientists met at the 7th Human Amyloid Imaging (HAI) meeting to share the most up-to-date research on brain imaging...
Paper Alert—HORIZON Trial Data Published
Researchers have formally published the results of the Phase 3 trial of Dimebon®, aka latrepirdine, in Huntington’s disease patients...
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