Sirtuin Bests Huntingtin in Tug-of-War for Neural Survival
An excess of sirtuin one-ups mutant huntingtin in mice, saving neurons and delaying Huntington’s disease...
6390 RESULTS
Sort By:
An excess of sirtuin one-ups mutant huntingtin in mice, saving neurons and delaying Huntington’s disease...
Sirtuins have been heralded as keys to longevity, based largely on studies in yeast, flies, and worms. New data now call these findings into question...
Polyphenols, plant compounds found in abundance in red wine and green tea, fight Aβ aggregation...
Is α-T catenin the elusive LOAD gene on chromosome 10? Or is it one of several genes? Read about Steve Younkin et al.'s presentation at the 8th International Conference on Alzheimer’s Disease and Related Disorders in Stockholm...
A parkinsonism-associated ubiquitin ligase interacts with parkin to promote mitophagy.
Researchers are finally getting a grip on the long-suspected link between mitochondria and not only PD, but other neurodegenerative diseases as well...
Rare variants of AD share some common areas of brain atrophy, but are also unique by way of degeneration in specific functional networks that correspond with clinical symptoms.
Is anyone, parent or physician, brave enough to allow gene therapy in newborn babies? The answer may come sooner than we think...
In spinal muscular atrophy (SMA), researchers have known for some time that motor neurons die for lack of the SMN (survival motor neuron) protein...
Extending in-vitro evidence that insulin-degrading enzyme (IDE) may be involved in the clearance of the Aβ peptide, a report in the 12 March issue of PNAS finds that IDE knockout mice have higher cerebral accumulation of both Aβ and the AβP intracellular domain...
In today’s Science, an international team of collaborators reports that accumulation of mutations in the mitochondrial genome may...
Scientists at the Yerkes National Primate Research Center in Atlanta, Georgia, have developed a primate model of Huntington disease...
The alternative splicing of β-secretase messenger RNA leads to the production of inactive forms of BACE1...
As outlined in two recent papers, ALS pathology is found far and wide...
Working independently, two European-led research groups may have uncovered an important clue to the mystery of amyotrophic lateral sclerosis (ALS)...