Iron Export? New Role Links APP, Metals, to Oxidative Stress
Amyloid precursor protein (APP) exports iron from neurons...
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Amyloid precursor protein (APP) exports iron from neurons...
One of the three iPSC consortia funded by the National Institute of Neurological Disorders and Stroke (NINDS) is creating lines for ALS...
New data may inspire some AD researchers to consider expanding their postmortem analyses to include tissue from a curious source—the liver...
While scientists are steaming ahead on establishing iPSC lines for research into PD and ALS, they have been more reluctant to embrace the technology for AD...
Since the discovery, in 2006, that adult cells could be reprogrammed to a pluripotent state, scientists have been excited by their potential...
Researchers are finding that Aβ and tau revolve more closely around each other than they had thought...
Despite recent setbacks on the clinical front, the hunt for small molecules that can cleanly tweak γ-secretase to slow AD seems to be alive and well...
A steady trickle of studies is building the case for mismanaged neuronal calcium as a trigger of synaptic troubles that contribute to Alzheimer disease...
In motor neuron disease, evidence is mounting that RNA processing lies at the heart of molecular pathogenesis...
Two genetic studies point squarely at the p arm of chromosome 9, where lurks an important risk factor for ALS...
Enhancing synaptic function might be a promising strategy to treat or prevent AD...
A paper reports the discovery of a γ-secretase activating protein (GSAP) that acts specifically to promote the binding of γ-secretase to APP, but not to Notch...
Researchers report that covalently constraining Aβ monomers into a specific β-hairpin structure accelerates formation of toxic oligomers...
The neurotransmitter norepinephrine seems to help resident phagocytes clear the Aβ peptides that accumulate in the brains of Alzheimer disease patients...
Non-pharmacologic approaches, such as one reported in this week’s JAMA, may yet offer the best hope for finding peace amid mental decline...