Route to toxicity converges with RNA binding proteins in membrane-less organelles.
The proposed budget would strike a blow to biomedical research, and science in general.
Tiny infarcts disrupt glymphatic clearance throughout the brain, allowing toxic waste to stick around and inflame surrounding tissue.
In a bizarre twist of cell biology, researchers find proteasomes in the neuronal plasma membrane. They pump signaling peptides into the extracellular space.
Study of disease subtypes boosts case for NfL as predictor of rapidly progressing ALS.
Primary care records from the last two decades show a slight boost in dementia diagnoses, although this may stem from increased recognition of the disease.
Mice carrying a human ApoE4 gene were more susceptible than those carrying ApoE3 to diabetes-related cognitive problems.
Mnemonic training reshapes functional connectivity patterns in the brain to facilitate recall akin to that found in memory athletes.
Restoring normal transport of BACE1-carrying endosomes prevents synapse loss and cognitive decline in mice.
Combining PET with MRI reveals near-complete overlap of tau tracer uptake with cortical atrophy and clinical features in typical and atypical AD.
If it works in neurons, this disposal pathway could have implications for neurodegenerative disease.
Quality control issues may have scuppered clinical trials.
NIH funds a five-year project to validate biomarkers for clinical trials.
ALS patients eliminate more p75 neurotrophin receptor than do healthy controls. P75 urine levels rise as disease worsens.
Going from normal zzzs to sleeping longer than nine hours a night more than doubles a person’s risk of developing dementia, study says.