In cell cultures, excess cytoplasmic TDP-43 shut down global translation and triggered formation of protein inclusions.
Transgenic mouse models devoid of gut microbes make fewer Aβ plaques.
Using yeast as springboard, researchers deploy a new computational tool to trace the biology driving α-synuclein pathology in people. The hope: to find pathways that will inform future therapies.
Speaking two languages enhances connections within the brain, which may compensate for neurodegeneration.
A simple blood draw may help distinguish garden-variety PD from other, less common parkinsonian disorders early in disease.
Neurons of the humble roundworm pack damaged organelles and protein aggregates into giant vesicles and heave them out into extracellular space. Do our neurons do that, too?
In rats, stimulation of astrocytes boosted the signal from micro-FDG PET, suggesting these scans may reflect more than just neuronal activity.
In induced cells from people with a C9ORF72 expansion, the number of mutant transcripts matched the number of RNA foci per cell.
The vascular cells, which die off in Alzheimer’s disease, may be crucial for regulating blood supply to the brain.
The acute state of confusion not only accelerates memory loss on its own, but also worsens decline caused by other pathologies, including Alzheimer’s disease.
A gene pegged at driving up AD risk may work by a different mechanism than originally published.
Solanezumab: Did Aβ ‘Reflux’ From Blood Confound Target Engagement in CSF? After Solanezumab: Where Should Alzheimer’s Research Go? At an expert meeting convened by Alzheimer’s Research UK, scientists from Eli Lilly shared Aβ biomarker data from the ...
Branch out, scientists at Alzheimer’s Research UK conference say. Go after tau, glial activation, lipids, in a systematic way. Understand how these pathways connect to the amyloid hypothesis.
Convened by ARUK to learn from the antibody’s billion-dollar bust, industry and academic leaders declare insufficient CNS target engagement, say peripheral sink did not work, and brainstorm how to move forward.
Describing the current and future toll of AD, a new PBS documentary advocates for drastic increases in research funding.