Injected α-synuclein fibrils triggered pathology throughout the mouse brain, even in regions not neuroanatomically connected to the injection site. Astrocytes were loaded with inclusions.
Immune cells lacking the receptor fail to respond to injury and aging, resulting in overall poor brain health in mouse models.
Protein Liquid-Liquid Phase Transitions: The Science Is About to Gel Confused about protein liquid-liquid phase transitions? You are not alone. Researchers working in this emerging field gathered in Leuven in early May to make sense of the latest data ...
At a topical meeting in Leuven, Belgium, a coherent picture began to emerge for how these membraneless organelles function in health and disease.
A veteran of the Battle of the Bulge, Terry trained legions of neuropathologists at Einstein and UCSD. He described paired helical filaments and linked synapse loss to cognitive decline.
Over the past 15 years, deaths attributable to Alzheimer’s have risen 55 percent, according to the CDC, and more people are living at home when they die, suggesting a need to support caregivers.
A study of nearly 80,000 individuals unearthed 52 genes tied to general intelligence, 40 of which are new.
Researchers implicate these innate immune cells in the disruption of neurovascular coupling by Aβ in mice.
Tyrosine kinase inhibitors kept diseased motor neurons alive in vitro, and notched positive findings in a recent Phase 3 trial. A new paradigm for ALS treatment?
By targeting distinct cell populations in the external globus pallidus, researchers restore mobility to a mouse model of Parkinson’s disease.
Ionis announced top-line results of a Phase 3 trial of their drug for familial amyloid neuropathy. It met both primary endpoints but caused serious side effects in some people.
A new fluorescent compound labels only non-contractile cells in the capillary bed, supporting the idea that these mysterious little cells do not directly regulate brain blood flow.
Chronic, low-dose Δ9-tetrahydrocannabinal reset gene expression through epigenetics, increased the number of synapses, and reversed age-related memory loss. Young mice showed no benefit.
Examining multiple α-synuclein disorders in a Midwestern population shows that some kill faster than others. The worst: MSA.
On the contrary, having AD may lead to low body mass index, according to a genetic randomization study.