Mice carrying a human ApoE4 gene were more susceptible than those carrying ApoE3 to diabetes-related cognitive problems.
Mnemonic training reshapes functional connectivity patterns in the brain to facilitate recall akin to that found in memory athletes.
Restoring normal transport of BACE1-carrying endosomes prevents synapse loss and cognitive decline in mice.
Combining PET with MRI reveals near-complete overlap of tau tracer uptake with cortical atrophy and clinical features in typical and atypical AD.
If it works in neurons, this disposal pathway could have implications for neurodegenerative disease.
Quality control issues may have scuppered clinical trials.
NIH funds a five-year project to validate biomarkers for clinical trials.
ALS patients eliminate more p75 neurotrophin receptor than do healthy controls. P75 urine levels rise as disease worsens.
Going from normal zzzs to sleeping longer than nine hours a night more than doubles a person’s risk of developing dementia, study says.
In AD mouse brain, transplanted human neurons develop more tau pathology and die more readily than neighboring mouse neurons.
Produced by the dreaded MRSA bacterium, PSMα3 is the first known example of a natural peptide that forms amyloid fibers made not of β-sheets, but of neatly stacked α-helices.
A well-controlled trials shows that a year of treatment offers no cognitive benefit for older men with low testosterone levels.
The extracellular fragment of TREM2, but not of its AD variants, promotes microglial survival, activation. To do that, it does not need the full-length TREM2 receptor.
Growing expansions in the C9ORF72 gene may lead to earlier onset of amyotrophic lateral sclerosis and/or frontotemporal dementia symptoms with each passing generation.
Thousands of hits on the ol’ noggin during a soccer player’s career might lead to concussive symptoms and, eventually, dementia.