Research Brief: Clusterin Grabs Spotlight Among Elite Few LOAD Genes
Among the few genes recently linked to late-onset Alzheimer disease (LOAD) in multiple genomewide screens, clusterin has stolen the show in two new papers...
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Going Nuclear: First Function for FUS Mutants
Large proteins need a key—in the form of a nuclear localization sequence—to unlock the transporters that let them into the cell’s inner sanctum...
Characterizing Consciousness: From Cognition to the Clinic
Consciousness is like beauty: We all know subjectively what it is, but it is very hard to define concisely...
Paper Alert: Toning Down β- and γ-Secretases
A compound that blocks both β- and γ-secretase might tone down production of amyloid-β (Aβ) and perhaps slow or prevent Alzheimer disease...
Studying the Oldest Old—Chances for Longevity Spelled Out in Genes?
As denim trumps other fabrics in durability and longevity, genes may beat the pants out of diet and lifestyle in determining whether you’ll live to 100...
ApoE, ApoE Receptors & Neurodegeneration
St. Louis: ApoE Receptors—Hold Sway Over Synaptic Function St. Louis: ApoE—Receptors, Theories and Therapies St. Louis: ApoE—A Clearer View of its Role In AD? The apolipoprotein E gene is the strongest genetic risk factor for late-onset Alzheimer disease.
St. Louis: ApoE—A Clearer View of its Role In AD?
ApoE receptors enable a flurry of activity, much of it totally independent of amyloid-β pathology...
Ginkgo Gambit—Do Claims Rest on Solid Data?
It failed in the large Ginkgo of Memory (GEM) prevention trial, but companies are still betting ginkgo biloba extract is a valuable anti-dementia agent...
Off BACE: Lack of Secretase Causes Seizures in Knockout Mice
A potential therapeutic strategy for Alzheimer disease (AD) is to inhibit the BACE enzymes that kickstart processing of amyloid precursor protein (APP) to form Aβ...
ALS Gene Expression and Biomarkers: A Better Way to Microarray?
Microarrays tantalize investigators with the promise of a new smorgasbord of genes to explore and proteins to target with therapeutics...
Serotonin Neurons—Culprits in Graft-Related Parkinson Dyskinesia
During the late 1980s and the 1990s, tissue grafts, chosen to replace lost dopaminergic neurons, seemed to show great promise for the treatment of Parkinson disease...
Mutant SOD1 Inflames If Not Quenched by Autophagy
Misfolded proteins can gum up the cell’s works by glomming together and boosting inflammation...
St. Louis: ApoE—Receptors, Theories and Therapies
ApoE stands out for a frustrating mark of distinction...
St. Louis: ApoE Receptors—Hold Sway Over Synaptic Function
The apolipoprotein E gene is the strongest genetic risk factor for late-onset Alzheimer disease...
Motor Neuron Disease Risk Factors: Fresh miRNA Clue, KIFAP3 Letdown
Sifting through the genome has netted several mutations responsible for motor neuron diseases, but scientists still cannot explain the cause for most incidences...
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