Connections across neural networks break down as cognition declines in people with different forms of AD, suggesting the wiring problems may be a hallmark of disease progression.
In gritty and sometimes harrowing detail, activist Meryl Comer describes the reality of caring for a loved one with Alzheimer’s disease.
Families considering PGD to avoid passing on disease genes face obstacles such as high cost and invasive procedures.
Several thousand people have used preimplantation genetic diagnosis to avoid passing on pathogenic mutations to their babies, but many families with a history of Alzheimer’s or related diseases remain unaware of this option.
The largest meta-analysis done to date confirms dramatic variability in age at onset of autosomal-dominant Alzheimer's disease overall, but finds mutation type and parental age at onset to be strong predictive modulators.