DIAN Part 3: Genetic and Data Protection for Volunteers
DIAN asks a lot of its study volunteers...
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Data in Disguise: As Results Roll In, DIAN Works to Guard Privacy
DIAN leaders wrestled with the sensitive issue of genetic confidentiality when reporting data in scientific publications...
Families Fight Back As Disease Claws at Next Generation
Families participating in the DIAN made an impassioned case for pressing on with clinical trials at two recent gatherings of the network...
Phoenix: Can Alzheimer’s Prevention Initiative Break a Catch-22?
The Alzheimer’s Prevention Initiative is a proposal to get serious about Alzheimer disease prevention research...
Clues from the Colombian Countryside
An enormous extended family living in a rural community in Colombia could provide new insights into environmental and genetic factors contributing to Alzheimer’s disease. All family members who were diagnosed...
Does It Fly? Age of Onset in PS-linked FAD Primarily Determined by Mutations
All presenilin mutations are not created equal. While over 130 mutations in the presenilin-1 (PS1) gene cause...
Movie Alert: Memories of Tomorrow Reviewed by Viewer with AD
Last Wednesday, the Japanese film <em>Memories of Tomorrow</em> premiered in Los Angeles, California...
eFAD News: Biomarkers May Help Pinpoint Disease Onset
People affected by early-onset familial forms (eFAD) often wonder how discoveries apply to them...
Spain Offers Study for Families With Monogenetic Dementia, eFAD
Interest in families stricken with autosomal-dominant Alzheimer disease has intensified in the past few years...
St. Louis: An eFAD Prevention Trial—One Man’s View
DIAN was founded with the hope that its participating families could be offered a prevention trial and/or treatment trial before too long...
New Genetic Insights Into AD: SORL1 and Natural Selection
Two papers published this month claim to identify those at greatest risk for Alzheimer’s disease and illuminate the mechanisms behind it...
DIAN Longitudinal Data Surprises With Late Drop in Tau
The first longitudinal data from DIAN conflict with some cross-sectional findings, revealing a small drop in CSF injury markers after the first appearance of symptoms of disease.
Inositol Triphosphate Receptor Blamed for Calcium Chaos in Alzheimer’s
By paring back calcium signaling, researchers prevented signs of Alzheimer’s in mice carrying a presenilin mutation. Could the strategy work in humans?
Preimplantation Genetic Diagnosis Can Stop Inherited Disease in a Family
Several thousand people have used preimplantation genetic diagnosis to avoid passing on pathogenic mutations to their babies, but many families with a history of Alzheimer’s or related diseases remain unaware of this option.
Preimplantation Genetic Diagnosis: It’s No Walk in the Park
Families considering PGD to avoid passing on disease genes face obstacles such as high cost and invasive procedures.
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