Preclinical Research Offers New Angles on Immunotherapy
Researchers at this year’s SfN meeting detailed different strategies and outcomes of passive and active vaccines.
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Researchers at this year’s SfN meeting detailed different strategies and outcomes of passive and active vaccines.
Trials of gene therapy for spinomuscular atrophy and stem cell treatments for ALS look promising.
At the International Dementia with Lewy Bodies conference in Fort Lauderdale, Florida, fuzzy images of dying sympathetic cardiac nerve terminals proved to be a sharp aide to clinch this notoriously difficult diagnosis.
Studies find that a drug in cough syrup can improve symptoms, and that radiation therapy safely shuts off a salivary gland.
At a DLB meeting, scientists reported progress in disentangling the notorious overlap in symptoms and pathology in this quintessential spectrum disease. (Hint: tangles are bad.)
How α-synuclein aggregates spread, quite possibly starting in the nose in some people, sets DLB apart from its better-known cousins, Alzheimer’s and Parkinson’s.
When clinicians and pathologists argue, sometimes genetics can settle the dispute. How about DLB?
The drug benefits some patients with mild amyotrophic lateral sclerosis, and is approved in Japan.
The prion concept continues to infiltrate the neurodegeneration field, with models of SOD1 propagation and a bevy of tau strains.
Using PET, researchers are trying to match tau spread against structural and functional defects.
Preliminary data suggests a long lag between Aβ and tau deposits as the disease develops.
AV1451 appears too weak to diagnose non-AD tauopathies.
Results raise the tentative prospect that a medical food might have possible cognitive benefit early in disease.
NAPA's latest collective exercise was a conference to update the field on progress in the past three years and advise the NIH on how to spend the next round of funds.
A bit less strapped for funding, researchers are considering the next steps for Lewy body, frontotemporal, and vascular dementia.