Alarmed by crushing screen failure rates of the first prodromal Alzheimer’s trials, EPAD and GAP are chasing new ways to reach people who don’t know they really should be in a secondary prevention trial.
This past year, the Global Alzheimer’s Platform and the European Prevention of Alzheimer’s Dementia have moved quickly, and jointly, to pave the way toward more, faster, cheaper trials. Will they be better, too?
At AAIC, researchers suggested splitting out the markers in a new staging scheme. Called ATN, it aims to clarify underlying causes of atypical dementias and suspected non-Alzheimer’s pathology (SNAP).
Claims of a positive effect in a small subgroup of patients are statistically meaningless, experts say.
At Keystone, researchers also linked the receptor to microglial homeostasis and migration, and resolved lingering questions about TREM2’s role in plaque clearance.
Researchers are discovering that microglia not only respond dramatically to their environment, but they also can quickly lose their identity.
At Keystone, researchers report the discovery of ion channels that shed light on the machinations of the brain’s microglia.
Seeking strength in numbers, families gathered to swap stories and to learn about an upcoming DIAN-TU therapy trial geared specifically to their particular form of early onset AD.
Three research groups turn induced pluripotent stem cells into what look like microglia.
A dynamic joint meeting dispels some old tenets while charting new avenues for research, such as microglia from iPSCs.
Zilkha conference features news on tau toxicity, a leaky blood-brain barrier, and the biology of pericytes.
After years of doubt, leading scientists are growing cautiously excited about the idea that bacteria might seed plaques.
Citing “fantastic opportunity,” FDA and EMA call for rigorous science. Agency scientists tell FTD Treatment Study Group: Explore individualized outcomes, and connect biomarkers to meaningful improvement.
Hoping for better luck in clinical trials than their Alzheimer’s colleagues had in the past decade, FTD researchers are now chasing biomarkers. It’s slim pickings so far, but neurofilament, tau PET, and MRI are showing promise.
At a workshop of the Frontotemporal Dementia Treatment Study Group, advocates and regulatory scientists urged leaders from industry and academia to forge a collaborative approach while the field is still young.