News Flash: Colombian Families Come to Phoenix for Amyloid PET
All those who follow the Alzheimer's Prevention Initiative may want to check out a recent New York Times article...
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Expanding the Network, DIAN Starts Showing Longitudinal Data
When the Dominantly Inherited Alzheimer Network gathered at the its hub at Washington University, St. Louis, Missouri, researchers exchanged new science on ARIA...
Phoenix: Trials in Colombia and the U.S. for Those at Highest Risk?
Researchers have laid out a vision for pre-symptomatic treatment trials that emphasize use of biomarkers to evaluate investigational drugs...
Research Brief: Did γ-Secretase Mutation Get Under Karl Marx’s Skin?
Could it be that a γ-secretase mutation helped give rise to communism?
Beyond γ-Secretase: FAD Mutations Affect Calcium Channel via Lipid Messenger
Mutations in presenilin associated with familial Alzheimer disease perturb calcium signaling in cells. In particular, some mutations suppress...
Research Brief: Auguste D.'s Mutation Identified?
Scientists propose that Auguste Deter, the first identified Alzheimer disease patient, carried the N141I presenilin-2 mutation...
In Cells, Late- and Early Onset Alzheimer’s Look Different
A new study suggests that early and late-onset forms of Alzheimer's disease may bear little resemblance at the molecular level...
All in the Family: Alois Alzheimer’s Second Patient Came from Extended Disease Pedigree
During his lifetime, Alois Alzheimer described five cases of the “characteristic sickness of the cerebral cortex” that his boss, the eminent psychiatrist Emil Kraepelin, later would name in honor of his late colleague. Now, neurologists in Alzheimer’s home state of Bavaria are investigating how these early patients’ family members fared. One patient, Johann F., turns out to have belonged to a large clan afflicted with an early-onset, heritable form of the disease. Many descendants still live in Bavaria, some in the U.S.
Family History Accounts for Some of the Spread in Age at Onset of Familial Alzheimer's
The largest meta-analysis done to date confirms dramatic variability in age at onset of autosomal-dominant Alzheimer's disease overall, but finds mutation type and parental age at onset to be strong predictive modulators.
CRISPR Edits Genome of Human Embryos
CRISPR-Cas9 gene editing rids embryos of a mutation causing heart disease, evoking a future where autosomal-dominant disease is prevented at the DNA level. What about AD, FTD, and ALS?
In Mice, CRISPR-Based Alzheimer’s Therapies Inch Forward
Researchers take first steps on road to targeting disease-causing APP mutations and amyloid processing.
Is APOB a Risk Gene for Early Onset Alzheimer’s?
Scientists link this mysterious form of dementia to higher plasma LDL-cholesterol, and to genetic variants in APOB, which encodes the major component of low-density lipoprotein.
Different CSF Phospho-Taus Match Distinct Changes in Brain Pathology
Different forms of p-tau in cerebrospinal fluid reflect worsening plaque load, metabolism, and atrophy in the brain. They could help stage Alzheimer’s disease.
Umbilical Cord With Presenilin Mutation Births New Cell Model of Familial AD
Umbilical cord stem cells from presenilin 1 E280A carriers, once differentiated into cholinergic-like neurons, pumped out Aβ42 and accumulated phosphorylated tau and apoptotic markers.
Introducing the Coarse-Grained Plaque—A New Type of Amyloid
Comprising mostly Aβ40, these large plaques are shot through with strange tubular structures and BBB markers. They are common in early onset AD.
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