Family History Increases Risk for Late-onset Alzheimer Disease
Having one parent with Alzheimer disease is hard enough; having two must be devastating...
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Having one parent with Alzheimer disease is hard enough; having two must be devastating...
The cyclin-dependent kinase Cdk5 has diverse functions in the brain, and has been implicated in Alzheimer disease in multiple contexts...
Researchers provide evidence that the same polyglutamine expansion mutation in ataxin can lead to simultaneous gain and loss of function...
Fragments of amyloid-β precursor protein (APP) previously associated with Alzheimer disease pathology are present at dramatically higher levels in the brains of young, perfectly normal adults...
New work implicates a novel endocytic pathway in the internalization of APP...
Thanks to a decade of work by advocates for public access, today a few keystrokes is all it takes to pull up a wealth of information about ongoing clinical trials...
Much of the data generated from drug trials on human volunteers stays hidden from view, sometimes to the detriment of patients...
In ALS and other neurodegenerative disorders, a newer player could be joining the current star under the limelight...
The capacity to generate action potentials, prime purview of neurons, is actually not exclusive to those cells...
Only one in 10,000 people gets to be serenaded with the “Happy Birthday” song for the 100th time...
Mitochondria get more than their fair share of the blame for neurodegeneration...
The MetLife Foundation recognized three scientists who advanced knowledge of the β- and γ-secretase enzymes...
Two major cellular pathways collude to regulate levels of the microtubule binding protein tau...
Researchers report that they have found mutations of the TAR DNA binding protein (TDP-43) in people with amyotrophic lateral sclerosis (ALS)...
It may be a bit of a leap, but could α-synuclein toxicity be mediated, at least in part, by amyloid-β (Aβ)?...
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