Capillary Clearing—Novel Mechanism a Link to Vascular Dementia?
Recently, researchers discovered a novel process that enables the mouse cerebral microvasculature to eliminate tiny blood clots and other debris...
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Recently, researchers discovered a novel process that enables the mouse cerebral microvasculature to eliminate tiny blood clots and other debris...
Scientists on an optimistic fishing expedition, involving 1,000 small molecules and hundreds of mice, have caught a big one with a chemical that promotes adult neurogenesis...
For research on age-related decline that hits closer to home, taxonomically and anatomically, check out two recent studies of rhesus monkeys in the Journal of Neuroscience...
Among the few genes recently linked to late-onset Alzheimer disease (LOAD) in multiple genomewide screens, clusterin has stolen the show in two new papers...
Large proteins need a key—in the form of a nuclear localization sequence—to unlock the transporters that let them into the cell’s inner sanctum...
Consciousness is like beauty: We all know subjectively what it is, but it is very hard to define concisely...
A compound that blocks both β- and γ-secretase might tone down production of amyloid-β (Aβ) and perhaps slow or prevent Alzheimer disease...
As denim trumps other fabrics in durability and longevity, genes may beat the pants out of diet and lifestyle in determining whether you’ll live to 100...
St. Louis: ApoE Receptors—Hold Sway Over Synaptic Function St. Louis: ApoE—Receptors, Theories and Therapies St. Louis: ApoE—A Clearer View of its Role In AD? The apolipoprotein E gene is the strongest genetic risk factor for late-onset Alzheimer disease.
ApoE receptors enable a flurry of activity, much of it totally independent of amyloid-β pathology...
It failed in the large Ginkgo of Memory (GEM) prevention trial, but companies are still betting ginkgo biloba extract is a valuable anti-dementia agent...
A potential therapeutic strategy for Alzheimer disease (AD) is to inhibit the BACE enzymes that kickstart processing of amyloid precursor protein (APP) to form Aβ...
Microarrays tantalize investigators with the promise of a new smorgasbord of genes to explore and proteins to target with therapeutics...
During the late 1980s and the 1990s, tissue grafts, chosen to replace lost dopaminergic neurons, seemed to show great promise for the treatment of Parkinson disease...
Misfolded proteins can gum up the cell’s works by glomming together and boosting inflammation...
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