All Comments by Takaomi Saido

  1. Dissociation of apolipoprotein E oligomers to monomer is required for high-affinity binding to phospholipid vesicles.
  2. Combinatorial Tau pseudophosphorylation: markedly different regulatory effects on microtubule assembly and dynamic instability than the sum of the individual parts.
  3. Two distinct amyloid beta-protein (Abeta) assembly pathways leading to oligomers and fibrils identified by combined fluorescence correlation spectroscopy, morphology, and toxicity analyses.
  4. What was lost in translation in the DHA trial is whom you should intend to treat.
  5. High ability of apolipoprotein E4 to stabilize amyloid-β peptide oligomers, the pathological entities responsible for Alzheimer's disease.
  6. Expression and functional profiling of neprilysin, insulin-degrading enzyme, and endothelin-converting enzyme in prospectively studied elderly and Alzheimer's brain.
  7. Law and Disorder—APPswe Patent Suits Raise Ruckus Again
  8. Lack of brain-to-blood efflux transport activity of low-density lipoprotein receptor-related protein-1 (LRP-1) for amyloid-beta peptide(1-40) in mouse: involvement of an LRP-1-independent pathway.
  9. Structure-neurotoxicity relationships of amyloid beta-protein oligomers.
  10. Neuropathology of nondemented aging: presumptive evidence for preclinical Alzheimer disease.
  11. Neprilysin overexpression inhibits plaque formation but fails to reduce pathogenic Abeta oligomers and associated cognitive deficits in human amyloid precursor protein transgenic mice.
  12. Amyloidogenic processing of amyloid precursor protein: evidence of a pivotal role of glutaminyl cyclase in generation of pyroglutamate-modified amyloid-beta.
  13. Abnormally phosphorylated tau is associated with neuronal and axonal loss in experimental autoimmune encephalomyelitis and multiple sclerosis.
  14. The amyloid-beta rise and gamma-secretase inhibitor potency depend on the level of substrate expression.
  15. Human membrane metallo-endopeptidase-like protein degrades both beta-amyloid 42 and beta-amyloid 40.