All Comments by Michael Wolfe

  1. Paper Alert: Verubecestat Preclinical and Phase 1 Data Published
  2. G-Protein Receptor Knockout Rescues Several Models of Alzheimer’s
  3. G-Protein Receptor Knockout Rescues Several Models of Alzheimer’s
  4. Structural basis of human γ-secretase assembly.
  5. Trans-dominant negative effects of pathogenic PSEN1 mutations on γ-secretase activity and Aβ production.
  6. Trans-dominant negative effects of pathogenic PSEN1 mutations on γ-secretase activity and Aβ production.
  7. Safety and Tolerability of the γ-Secretase Inhibitor Avagacestat in a Phase 2 Study of Mild to Moderate Alzheimer Disease.
  8. The crystal structure of GXGD membrane protease FlaK.
  9. Three-amino acid spacing of presenilin endoproteolysis suggests a general stepwise cleavage of gamma-secretase-mediated intramembrane proteolysis.
  10. Functional analysis of the transmembrane domains of presenilin 1: participation of transmembrane domains 2 and 6 in the formation of initial substrate-binding site of gamma-secretase.
  11. Beta-amyloid precursor protein mutants respond to gamma-secretase modulators.
  12. An APP inhibitory domain containing the Flemish mutation residue modulates gamma-secretase activity for Abeta production.
  13. Dual Secretase Approach Shows Promise in AD Mice
  14. gamma-Secretase: successive tripeptide and tetrapeptide release from the transmembrane domain of beta-carboxyl terminal fragment.
  15. Amyloid precursor protein secretases as therapeutic targets for traumatic brain injury.