All Comments by Lawrence Rajendran

  1. Pharmacological chaperones stabilize retromer to limit APP processing.
  2. New Look into Early AD Reveals Lateral Entorhinal Cortex Vulnerability
  3. Phosphatidylinositol-3-phosphate regulates sorting and processing of amyloid precursor protein through the endosomal system.
  4. Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model.
  5. A multimodal RAGE-specific inhibitor reduces amyloid β-mediated brain disorder in a mouse model of Alzheimer disease.
  6. ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1.
  7. Aβ(1-42) inhibition of LTP is mediated by a signaling pathway involving caspase-3, Akt1 and GSK-3β.
  8. Cell-produced alpha-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival.
  9. Analysis of the gamma-secretase interactome and validation of its association with tetraspanin-enriched microdomains.
  10. Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein.
  11. BACE Inhibitors Hitch Ride into Endosomes via Membrane Anchor
  12. Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression.
  13. An alternative interpretation of the amyloid Abeta hypothesis with regard to the pathogenesis of Alzheimer's disease.
  14. Messing with the Membrane—An Alternative Interpretation of the Amyloid-β Hypothesis