All Comments by Edward Koo
- Mutant ubiquitin found in neurodegenerative disorders is a ubiquitin fusion degradation substrate that blocks proteasomal degradation.
- Postischemic hyperthermia induces Alzheimer-like pathology in the rat brain.
- Alpha-synuclein-immunoreactive deposits in human and animal prion diseases.
- Peeling plaque. Researchers remain optimistic about a vaccine against Alzheimer's.
- FAD mutant PS-1 gene-targeted mice: increased A beta 42 and A beta deposition without APP overproduction.
- APP transgenic mice Tg2576 accumulate Abeta peptides that are distinct from the chemically modified and insoluble peptides deposited in Alzheimer's disease senile plaques.
- Molecular neuropathology of transgenic mouse models of Down syndrome.
- Loss of basal forebrain P75(NTR) immunoreactivity in subjects with mild cognitive impairment and Alzheimer's disease.
- FAD mutations in presenilin-1 or amyloid precursor protein decrease the efficacy of a gamma-secretase inhibitor: evidence for direct involvement of PS1 in the gamma-secretase cleavage complex.
- Preimplantation diagnosis for early-onset Alzheimer disease caused by V717L mutation.
- Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins.
- Environmental enrichment slows disease progression in R6/2 Huntington's disease mice.
- Role of the omentum in the treatment of Alzheimer's disease.
- Head circumference and incident Alzheimer's disease: modification by apolipoprotein E.
- Calpain-mediated degradation of p35 to p25 in postmortem human and rat brains.