All Comments by Bart De Strooper
- Gene expression. MicroRNA control of protein expression noise.
- Presenilin-1 knockin mice reveal loss-of-function mechanism for familial Alzheimer's disease.
- Semagacestat Failure Analysis: Should γ-Secretase Remain a Target?
- A neuroprotective role for microRNA miR-1000 mediated by limiting glutamate excitotoxicity.
- An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease.
- Scientists Pinpoint γ-Secretase Modulator Binding Spot
- CTAD: New Data on Sola, Bapi, Spark Theragnostics Debate
- Pyromania: PyroGluAβ Toxicity is Prion-Like, Depends on Tau
- Identification of a tetratricopeptide repeat-like domain in the nicastrin subunit of γ-secretase using synthetic antibodies.
- Testing the right target and right drug at the right stage.
- Activation and intrinsic gamma-secretase activity of presenilin 1.
- Research Brief: Did γ-Secretase Mutation Get Under Karl Marx’s Skin?
- Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease.
- Lilly Halts IDENTITY Trials as Patients Worsen on Secretase Inhibitor
- ADAM10 is the physiologically relevant, constitutive alpha-secretase of the amyloid precursor protein in primary neurons.