All Comments by Bart De Strooper

  1. Lilly Halts IDENTITY Trials as Patients Worsen on Secretase Inhibitor
  2. ADAM10 is the physiologically relevant, constitutive alpha-secretase of the amyloid precursor protein in primary neurons.
  3. Three-amino acid spacing of presenilin endoproteolysis suggests a general stepwise cleavage of gamma-secretase-mediated intramembrane proteolysis.
  4. Characterizing the appearance and growth of amyloid plaques in APP/PS1 mice.
  5. Perpetrator and Savior—Presenilins Cut Both Ways
  6. Widespread changes in protein synthesis induced by microRNAs.
  7. Keystone: γ Slowly Relinquishes Its Secrets
  8. The presenilin hypothesis of Alzheimer's disease: evidence for a loss-of-function pathogenic mechanism.
  9. Structure of the catalytic pore of gamma-secretase probed by the accessibility of substituted cysteines.
  10. Gain or Loss of Function—Time to Shake up Assumptions on γ-Secretase in Alzheimer Disease?
  11. Equimolar production of amyloid beta-protein and amyloid precursor protein intracellular domain from beta-carboxyl-terminal fragment by gamma-secretase.
  12. Gain or Loss of Function—Time to Shake up Assumptions on γ-Secretase in Alzheimer Disease?
  13. Nicastrin—A DAPper Role in γ-Secretase
  14. The Senility-Presenilin Connection Turned Upside Down
  15. Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease.