All Comments by Nikolaos K. Robakis

  1. Genetic studies on chromosome 12 in late-onset Alzheimer disease.
  2. Treatment of Alzheimer's disease.
  3. Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons.
  4. Genetic association between alpha-2 macroglobulin and Japanese sporadic Alzheimer's disease.
  5. A protein kinase, PKN, accumulates in Alzheimer neurofibrillary tangles and associated endoplasmic reticulum-derived vesicles and phosphorylates tau protein.
  6. Inhibition of platelet activation by the Alzheimer's disease amyloid precursor protein.
  7. The HHQK domain of beta-amyloid provides a structural basis for the immunopathology of Alzheimer's disease.
  8. Evidence that intramolecular associations between presenilin domains are obligatory for endoproteolytic processing.
  9. Immunologic treatment of Alzheimer's disease.
  10. Apolipoprotein E isoform-specific reduction of extracellular amyloid in neuronal cultures.
  11. Overexpression of tau protein inhibits kinesin-dependent trafficking of vesicles, mitochondria, and endoplasmic reticulum: implications for Alzheimer's disease.
  12. Loss of somatostatin-like immunoreactivity in the frontal cortex of Alzheimer patients carrying the apolipoprotein epsilon 4 allele.
  13. Melatonin protects hippocampal neurons in vivo against kainic acid-induced damage in mice.
  14. Neuronal overexpression of mutant amyloid precursor protein results in prominent deposition of cerebrovascular amyloid.
  15. C-terminal maturation fragments of presenilin 1 and 2 control secretion of APP alpha and A beta by human cells and are degraded by proteasome.