All Comments by Nikolaos K. Robakis

  1. Senile dementia with tangles (tangle predominant form of senile dementia).
  2. Expression profiles of multiple genes in single neurons of Alzheimer's disease.
  3. Prostaglandins act as neurotoxin for differentiated neuroblastoma cells in culture and increase levels of ubiquitin and beta-amyloid.
  4. Treatment of Alzheimer's disease.
  5. Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons.
  6. Genetic studies on chromosome 12 in late-onset Alzheimer disease.
  7. A protein kinase, PKN, accumulates in Alzheimer neurofibrillary tangles and associated endoplasmic reticulum-derived vesicles and phosphorylates tau protein.
  8. Inhibition of platelet activation by the Alzheimer's disease amyloid precursor protein.
  9. Genetic association between alpha-2 macroglobulin and Japanese sporadic Alzheimer's disease.
  10. The HHQK domain of beta-amyloid provides a structural basis for the immunopathology of Alzheimer's disease.
  11. Evidence that intramolecular associations between presenilin domains are obligatory for endoproteolytic processing.
  12. Immunologic treatment of Alzheimer's disease.
  13. Apolipoprotein E isoform-specific reduction of extracellular amyloid in neuronal cultures.
  14. Overexpression of tau protein inhibits kinesin-dependent trafficking of vesicles, mitochondria, and endoplasmic reticulum: implications for Alzheimer's disease.
  15. Loss of somatostatin-like immunoreactivity in the frontal cortex of Alzheimer patients carrying the apolipoprotein epsilon 4 allele.