All Comments by Nikolaos K. Robakis

  1. A protein kinase, PKN, accumulates in Alzheimer neurofibrillary tangles and associated endoplasmic reticulum-derived vesicles and phosphorylates tau protein.
  2. Inhibition of platelet activation by the Alzheimer's disease amyloid precursor protein.
  3. The HHQK domain of beta-amyloid provides a structural basis for the immunopathology of Alzheimer's disease.
  4. Evidence that intramolecular associations between presenilin domains are obligatory for endoproteolytic processing.
  5. Immunologic treatment of Alzheimer's disease.
  6. Apolipoprotein E isoform-specific reduction of extracellular amyloid in neuronal cultures.
  7. Overexpression of tau protein inhibits kinesin-dependent trafficking of vesicles, mitochondria, and endoplasmic reticulum: implications for Alzheimer's disease.
  8. Loss of somatostatin-like immunoreactivity in the frontal cortex of Alzheimer patients carrying the apolipoprotein epsilon 4 allele.
  9. Neuronal overexpression of mutant amyloid precursor protein results in prominent deposition of cerebrovascular amyloid.
  10. C-terminal maturation fragments of presenilin 1 and 2 control secretion of APP alpha and A beta by human cells and are degraded by proteasome.
  11. Melatonin protects hippocampal neurons in vivo against kainic acid-induced damage in mice.
  12. Rapid tau protein dephosphorylation and differential rephosphorylation during cardiac arrest-induced cerebral ischemia and reperfusion.
  13. Increased levels of apolipoprotein D in cerebrospinal fluid and hippocampus of Alzheimer's patients.
  14. Carnosine, a protective, anti-ageing peptide?
  15. Evidence for an Alzheimer disease susceptibility locus on chromosome 12 and for further locus heterogeneity.