All Comments by John Hardy

  1. Prion protein protects human neurons against Bax-mediated apoptosis.
  2. A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease.
  3. tau Exon 10 expression involves a bipartite intron 10 regulatory sequence and weak 5' and 3' splice sites.
  4. Identification of a novel family of presenilin homologues.
  5. A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain.
  6. Determinants of 4-repeat tau expression. Coordination between enhancing and inhibitory splicing sequences for exon 10 inclusion.
  7. SNPing away at complex diseases: analysis of single-nucleotide polymorphisms around APOE in Alzheimer disease.
  8. Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo.
  9. Beta-amyloid precursor protein, ETS-2 and collagen alpha 1 (VI) chain precursor, encoded on chromosome 21, are not overexpressed in fetal Down syndrome: further evidence against gene dosage effect.
  10. Reduced effectiveness of Abeta1-42 immunization in APP transgenic mice with significant amyloid deposition.
  11. Synucleins are a novel class of substrates for G protein-coupled receptor kinases.
  12. Effect of APOE genotype and promoter polymorphism on risk of Alzheimer's disease.
  13. Familial Danish dementia: a novel form of cerebral amyloidosis associated with deposition of both amyloid-Dan and amyloid-beta.
  14. Incidence of dementia and Alzheimer disease in 2 communities: Yoruba residing in Ibadan, Nigeria, and African Americans residing in Indianapolis, Indiana.
  15. Use of lipid-lowering agents, indication bias, and the risk of dementia in community-dwelling elderly people.