All Comments by John Hardy

  1. The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility.
  2. Loss of spr-5 bypasses the requirement for the C.elegans presenilin sel-12 by derepressing hop-1.
  3. Calcium dyshomeostasis and intracellular signalling in Alzheimer's disease.
  4. Amyloid-beta immunotherapy for Alzheimer's disease: the end of the beginning.
  5. Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch.
  6. Genome survey for susceptibility loci for recurrent, early-onset major depression: results at 10cM resolution.
  7. Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members.
  8. Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1.
  9. Reduction of Abeta accumulation in the Tg2576 animal model of Alzheimer's disease after oral administration of the phosphatidyl-inositol kinase inhibitor wortmannin.
  10. Growth arrest of individual senile plaques in a model of Alzheimer's disease observed by in vivo multiphoton microscopy.
  11. Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation.
  12. Inclusion body myositis-like phenotype induced by transgenic overexpression of beta APP in skeletal muscle.
  13. Tau is essential to beta -amyloid-induced neurotoxicity.
  14. SNP association studies in Alzheimer's disease highlight problems for complex disease analysis.
  15. beta-amyloid peptides enhance alpha-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease.