All Comments by John Hardy

  1. Growth arrest of individual senile plaques in a model of Alzheimer's disease observed by in vivo multiphoton microscopy.
  2. Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation.
  3. Inclusion body myositis-like phenotype induced by transgenic overexpression of beta APP in skeletal muscle.
  4. Tau is essential to beta -amyloid-induced neurotoxicity.
  5. SNP association studies in Alzheimer's disease highlight problems for complex disease analysis.
  6. beta-amyloid peptides enhance alpha-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease.
  7. Prion protein protects human neurons against Bax-mediated apoptosis.
  8. A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease.
  9. tau Exon 10 expression involves a bipartite intron 10 regulatory sequence and weak 5' and 3' splice sites.
  10. Identification of a novel family of presenilin homologues.
  11. Beta-amyloid precursor protein, ETS-2 and collagen alpha 1 (VI) chain precursor, encoded on chromosome 21, are not overexpressed in fetal Down syndrome: further evidence against gene dosage effect.
  12. Reduced effectiveness of Abeta1-42 immunization in APP transgenic mice with significant amyloid deposition.
  13. Synucleins are a novel class of substrates for G protein-coupled receptor kinases.
  14. Effect of APOE genotype and promoter polymorphism on risk of Alzheimer's disease.
  15. Familial Danish dementia: a novel form of cerebral amyloidosis associated with deposition of both amyloid-Dan and amyloid-beta.