All Comments by John Hardy

  1. Calcium dyshomeostasis and intracellular signalling in Alzheimer's disease.
  2. Amyloid-beta immunotherapy for Alzheimer's disease: the end of the beginning.
  3. Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch.
  4. Genome survey for susceptibility loci for recurrent, early-onset major depression: results at 10cM resolution.
  5. Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members.
  6. Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1.
  7. Reduction of Abeta accumulation in the Tg2576 animal model of Alzheimer's disease after oral administration of the phosphatidyl-inositol kinase inhibitor wortmannin.
  8. Growth arrest of individual senile plaques in a model of Alzheimer's disease observed by in vivo multiphoton microscopy.
  9. Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation.
  10. Inclusion body myositis-like phenotype induced by transgenic overexpression of beta APP in skeletal muscle.
  11. Tau is essential to beta -amyloid-induced neurotoxicity.
  12. SNP association studies in Alzheimer's disease highlight problems for complex disease analysis.
  13. beta-amyloid peptides enhance alpha-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease.
  14. Prion protein protects human neurons against Bax-mediated apoptosis.
  15. A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease.