All Comments by John Hardy

  1. D90A-SOD1 mediated amyotrophic lateral sclerosis: a single founder for all cases with evidence for a Cis-acting disease modifier in the recessive haplotype.
  2. The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility.
  3. Loss of spr-5 bypasses the requirement for the C.elegans presenilin sel-12 by derepressing hop-1.
  4. Calcium dyshomeostasis and intracellular signalling in Alzheimer's disease.
  5. Amyloid-beta immunotherapy for Alzheimer's disease: the end of the beginning.
  6. Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch.
  7. Genome survey for susceptibility loci for recurrent, early-onset major depression: results at 10cM resolution.
  8. Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members.
  9. Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1.
  10. Reduction of Abeta accumulation in the Tg2576 animal model of Alzheimer's disease after oral administration of the phosphatidyl-inositol kinase inhibitor wortmannin.
  11. Growth arrest of individual senile plaques in a model of Alzheimer's disease observed by in vivo multiphoton microscopy.
  12. Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation.
  13. Inclusion body myositis-like phenotype induced by transgenic overexpression of beta APP in skeletal muscle.
  14. Tau is essential to beta -amyloid-induced neurotoxicity.
  15. SNP association studies in Alzheimer's disease highlight problems for complex disease analysis.