All Comments by John Cirrito

  1. From Garbage Disposal to Neuromodulation? Membrane Proteasomes Churn Out Stimulating Peptides
  2. Regulation of presynaptic Ca2+, synaptic plasticity and contextual fear conditioning by a N-terminal β-amyloid fragment.
  3. Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins.
  4. Endocytosis Pulls α-Secretase From Synapses
  5. A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β.
  6. Neurotoxicity and memory deficits induced by soluble low-molecular-weight amyloid-β1-42 oligomers are revealed in vivo by using a novel animal model.
  7. Research Brief: Robots Trained in Patch-Clamp Experiments
  8. Arc/Arg3.1 regulates an endosomal pathway essential for activity-dependent β-amyloid generation.
  9. Cerebral amyloid-β proteostasis is regulated by the membrane transport protein ABCC1 in mice.
  10. Synaptic autoregulation by metalloproteases and γ-secretase.
  11. Synaptic activity reduces intraneuronal Abeta, promotes APP transport to synapses, and protects against Abeta-related synaptic alterations.
  12. Corticotropin-releasing factor receptors differentially regulate stress-induced tau phosphorylation.
  13. Amyloid precursor protein overexpression depresses excitatory transmission through both presynaptic and postsynaptic mechanisms.