All Comments by Takaomi Saido
- Abeta40 protects non-toxic Abeta42 monomer from aggregation.
- Effects of hypoxia and oxidative stress on expression of neprilysin in human neuroblastoma cells and rat cortical neurones and astrocytes.
- Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model.
- GSK3beta activity modifies the localization and function of presenilin 1.
- The presenilin hypothesis of Alzheimer's disease: evidence for a loss-of-function pathogenic mechanism.
- Implications of co-morbidity for etiology and treatment of neurodegenerative diseases with multifunctional neuroprotective-neurorescue drugs; ladostigil.
- Anatomical integration of newly generated dentate granule neurons following traumatic brain injury in adult rats and its association to cognitive recovery.
- The proline-rich domain and the microtubule binding domain of protein tau acting as RNA binding domains.
- The DYRK1A gene, encoded in chromosome 21 Down syndrome critical region, bridges between beta-amyloid production and tau phosphorylation in Alzheimer disease.
- On the seeding and oligomerization of pGlu-amyloid peptides (in vitro).
- Enhanced amyloidogenic metabolism of the amyloid beta-protein precursor in the X11L-deficient mouse brain.
- Unraveling in vivo functions of amyloid precursor protein: insights from knockout and knockdown studies.
- A genomic screen for modifiers of tauopathy identifies puromycin-sensitive aminopeptidase as an inhibitor of tau-induced neurodegeneration.
- Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer's disease brain is associated with mitochondrial dysfunction.
- Studies to investigate the in vivo therapeutic window of the gamma-secretase inhibitor N2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide (LY411,575) in the CRND8 mouse.