All Comments by Ilya Bezprozvanny

  1. Mutant Presenilin Skews Calcium Homeostasis by Chomping on ER Sensor
  2. Shielding Synaptic Glutamate Receptor from Aβ Preserves Memory in Mice
  3. Reversal of Aging-Related Neuronal Ca2+ Dysregulation and Cognitive Impairment by Delivery of a Transgene Encoding FK506-Binding Protein 12.6/1b to the Hippocampus.
  4. Presenilin-1 knockin mice reveal loss-of-function mechanism for familial Alzheimer's disease.
  5. ER-mitochondria associations are regulated by the VAPB-PTPIP51 interaction and are disrupted by ALS/FTD-associated TDP-43.
  6. Cytotoxicity of intracellular aβ42 amyloid oligomers involves Ca2+ release from the endoplasmic reticulum by stimulated production of inositol trisphosphate.
  7. First Crystal Structure of a Presenilin
  8. Early presynaptic and postsynaptic calcium signaling abnormalities mask underlying synaptic depression in presymptomatic Alzheimer's disease mice.
  9. Single-channel Ca(2+) imaging implicates Aβ1-42 amyloid pores in Alzheimer's disease pathology.
  10. A synaptic vesicle-associated Ca2+ channel promotes endocytosis and couples exocytosis to endocytosis.
  11. Presenilins, Ryanodine Receptors—Conspirators in Neurotransmission?
  12. Perpetrator and Savior—Presenilins Cut Both Ways
  13. NAADP mobilizes calcium from acidic organelles through two-pore channels.
  14. A polymorphism in CALHM1 influences Ca2+ homeostasis, Abeta levels, and Alzheimer's disease risk.
  15. Mechanism of Ca2+ disruption in Alzheimer's disease by presenilin regulation of InsP3 receptor channel gating.