All Comments by Elliott Mufson

  1. Axonally synthesized ATF4 transmits a neurodegenerative signal across brain regions.
  2. A multimodal RAGE-specific inhibitor reduces amyloid β-mediated brain disorder in a mouse model of Alzheimer disease.
  3. Testing the right target and right drug at the right stage.
  4. Anti-Aβ Oligomer Headed for Phase 3 Clinical Trial
  5. Amyloid-beta peptide oligomers disrupt axonal transport through an NMDA receptor-dependent mechanism that is mediated by glycogen synthase kinase 3beta in primary cultured hippocampal neurons.
  6. Caspase activation precedes and leads to tangles.
  7. Paper Alert-cum-SfN: Bapineuzumab Published, More AN1792 Presented
  8. The Alzheimer's disease-associated amyloid beta-protein is an antimicrobial peptide.
  9. Gambogic amide, a selective agonist for TrkA receptor that possesses robust neurotrophic activity, prevents neuronal cell death.
  10. eFAD Research Surprise: In Mutation Carriers, Amyloid Starts in Striatum
  11. Salzburg Overview: 8th International Conference Draws Record Number
  12. In vivo restoration of physiological levels of truncated TrkB.T1 receptor rescues neuronal cell death in a trisomic mouse model.
  13. Looking outside the Brain for Early Signs of AD
  14. The neurotrophin receptor p75NTR modulates long-term depression and regulates the expression of AMPA receptor subunits in the hippocampus.
  15. Cell-cycle reentry and cell death in transgenic mice expressing nonmutant human tau isoforms.