All Comments by Hiroshi Mori

  1. An Alzheimer's disease-linked PS1 variant rescues the developmental abnormalities of PS1-deficient embryos.
  2. Opposite roles of apolipoprotein E in normal brains and in Alzheimer's disease.
  3. Neurotrophic factors [activity-dependent neurotrophic factor (ADNF) and basic fibroblast growth factor (bFGF)] interrupt excitotoxic neurodegenerative cascades promoted by a PS1 mutation.
  4. Wide range of disease onset in a family with Alzheimer disease and a His163Tyr mutation in the presenilin-1 gene.
  5. Pathologic amyloid beta-protein cell surface fibril assembly on cultured human cerebrovascular smooth muscle cells.
  6. The effects of aging and neurodegeneration on apoptosis-associated DNA fragmentation and the benefits of nicotinamide.
  7. No association detected between very-low-density lipoprotein receptor (VLDL-R) and late-onset Alzheimer's disease in Hong Kong Chinese.
  8. Evidence for presenilin-1 involvement in amyloid angiopathy in the Alzheimer's disease-affected brain.
  9. The apolipoprotein E epsilon4 allele is not a significant risk factor for frontotemporal dementia.
  10. Sequential phosphorylation of Tau by glycogen synthase kinase-3beta and protein kinase A at Thr212 and Ser214 generates the Alzheimer-specific epitope of antibody AT100 and requires a paired-helical-filament-like conformation.
  11. The beta-amyloid precursor protein of Alzheimer's disease enhances neuron viability and modulates neuronal polarity.
  12. Estrogen blocks neurotoxic effects of beta-amyloid (1-42) and induces neurite extension on B103 cells.
  13. Cerebrovascular muscle atrophy is a feature of Alzheimer's disease.
  14. Mechanism and prevention of neurotoxicity caused by beta-amyloid peptides: relation to Alzheimer's disease.
  15. Inflammatory responses to amyloidosis in a transgenic mouse model of Alzheimer's disease.