All Comments by Hiroshi Mori

  1. An region upstream of the gene promoter for the beta-amyloid precursor protein interacts with proteins from nuclear extracts of the human brain and PC12 cells.
  2. Human amyloid precursor-like protein 1--cDNA cloning, ectopic expression in COS-7 cells and identification of soluble forms in the cerebrospinal fluid.
  3. Multiple pathways of apoptosis in PC12 cells. CrmA inhibits apoptosis induced by beta-amyloid.
  4. No association detected between very-low-density lipoprotein receptor (VLDL-R) and late-onset Alzheimer's disease in Hong Kong Chinese.
  5. Evidence for presenilin-1 involvement in amyloid angiopathy in the Alzheimer's disease-affected brain.
  6. Superoxide mediates the cell-death-enhancing action of presenilin-1 mutations.
  7. Presenilin 1 mutations linked to familial Alzheimer's disease increase the intracellular levels of amyloid beta-protein 1-42 and its N-terminally truncated variant(s) which are generated at distinct sites.
  8. Dementia with Lewy bodies.
  9. Amyloid plaques in Guam amyotrophic lateral sclerosis/parkinsonism-dementia complex contain species of A beta similar to those found in the amyloid plaques of Alzheimer's disease and pathological aging.
  10. Amyloid beta-protein toxicity and oxidative stress in Alzheimer's disease.
  11. Interaction of apolipoprotein E epsilon 4 with other genetic and non-genetic risk factors in late onset Alzheimer disease: problems facing the investigator.
  12. Levels of trkA and BDNF mRNA, but not NGF mRNA, fluctuate across the estrous cycle and increase in response to acute hormone replacement.
  13. Mechanism of action of antiinflammatory drugs.
  14. Oligomerization of endogenous and synthetic amyloid beta-protein at nanomolar levels in cell culture and stabilization of monomer by Congo red.
  15. Par-4 is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer disease.