All Comments by Hiroshi Mori

  1. Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response.
  2. Estrogens stabilize mitochondrial function and protect neural cells against the pro-apoptotic action of mutant presenilin-1.
  3. Free radicals and superoxide dismutase in blood of patients with Alzheimer's disease and vascular dementia.
  4. Genetic risk factors in Japanese Alzheimer's disease patients: alpha1-ACT, VLDLR, and ApoE.
  5. Alzheimer's presenilin-1 mutation potentiates inositol 1,4,5-trisphosphate-mediated calcium signaling in Xenopus oocytes.
  6. Stable association of presenilin derivatives and absence of presenilin interactions with APP.
  7. Solution structure of amyloid beta-peptide(1-40) in a water-micelle environment. Is the membrane-spanning domain where we think it is?
  8. Neuronal DNA damage precedes tangle formation and is associated with up-regulation of nitrotyrosine in Alzheimer's disease brain.
  9. Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins.
  10. Increased vulnerability of hippocampal neurons from presenilin-1 mutant knock-in mice to amyloid beta-peptide toxicity: central roles of superoxide production and caspase activation.
  11. Alzheimer disease: quantitative H-1 MR spectroscopic imaging of frontoparietal brain.
  12. Complete genomic screen in late-onset familial Alzheimer's disease.
  13. Heparin-binding properties of the amyloidogenic peptides Abeta and amylin. Dependence on aggregation state and inhibition by Congo red.
  14. Mutation screening in exons 3 and 4 of alpha-synuclein in sporadic Parkinson's and sporadic and familial dementia with Lewy bodies cases.
  15. The effect of estrogen replacement therapy on cognitive function in women: a critical review of the literature.