All Comments by Hiroshi Mori

  1. Opposite roles of apolipoprotein E in normal brains and in Alzheimer's disease.
  2. Neurotrophic factors [activity-dependent neurotrophic factor (ADNF) and basic fibroblast growth factor (bFGF)] interrupt excitotoxic neurodegenerative cascades promoted by a PS1 mutation.
  3. Wide range of disease onset in a family with Alzheimer disease and a His163Tyr mutation in the presenilin-1 gene.
  4. Pathologic amyloid beta-protein cell surface fibril assembly on cultured human cerebrovascular smooth muscle cells.
  5. The effects of aging and neurodegeneration on apoptosis-associated DNA fragmentation and the benefits of nicotinamide.
  6. Fibrilization in mouse senile amyloidosis is fibril conformation-dependent.
  7. Evidence for presenilin-1 involvement in amyloid angiopathy in the Alzheimer's disease-affected brain.
  8. The apolipoprotein E epsilon4 allele is not a significant risk factor for frontotemporal dementia.
  9. Sequential phosphorylation of Tau by glycogen synthase kinase-3beta and protein kinase A at Thr212 and Ser214 generates the Alzheimer-specific epitope of antibody AT100 and requires a paired-helical-filament-like conformation.
  10. The beta-amyloid precursor protein of Alzheimer's disease enhances neuron viability and modulates neuronal polarity.
  11. Estrogen blocks neurotoxic effects of beta-amyloid (1-42) and induces neurite extension on B103 cells.
  12. Cerebrovascular muscle atrophy is a feature of Alzheimer's disease.
  13. Mechanism and prevention of neurotoxicity caused by beta-amyloid peptides: relation to Alzheimer's disease.
  14. Inflammatory responses to amyloidosis in a transgenic mouse model of Alzheimer's disease.
  15. The presenilin 1 mutation (M146V) linked to familial Alzheimer's disease attenuates the neuronal differentiation of NTera 2 cells.