All Comments by Hiroshi Mori

  1. Apolipoprotein E promotes the binding and uptake of beta-amyloid into Chinese hamster ovary cells in an isoform-specific manner.
  2. Alpha-2 macroglobulin is genetically associated with Alzheimer disease.
  3. Altered cholesterol metabolism in human apolipoprotein E4 knock-in mice.
  4. Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo.
  5. Presenilins interact with armadillo proteins including neural-specific plakophilin-related protein and beta-catenin.
  6. mtDNA polymorphisms in Japanese sporadic Alzheimer's disease.
  7. Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: increased susceptibility of females.
  8. Antioxidant mechanisms in apolipoprotein E deficient mice prior to and following closed head injury.
  9. Interaction of tau with the neural membrane cortex is regulated by phosphorylation at sites that are modified in paired helical filaments.
  10. Reduction in amyloid A amyloid formation in apolipoprotein-E-deficient mice.
  11. Relationship between apolipoprotein E and the amyloid deposits and dystrophic neurites of Alzheimer's disease.
  12. Interaction of human alpha-Synuclein and Parkinson's disease variants with phospholipids. Structural analysis using site-directed mutagenesis.
  13. Region- and cell-type-specific pattern of tau phosphorylation in dog brain.
  14. Subcellular distribution and turnover of presenilins in transfected cells.
  15. Human apolipoprotein E allele-specific brain expressing transgenic mice.