All Comments by Hiroshi Mori

  1. Impairments in learning and memory accompanied by neurodegeneration in mice transgenic for the carboxyl-terminus of the amyloid precursor protein.
  2. Contrasting role of presenilin-1 and presenilin-2 in neuronal differentiation in vitro.
  3. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity.
  4. Structural analysis of Alzheimer's beta(1-40) amyloid: protofilament assembly of tubular fibrils.
  5. Protective effects of idebenone and alpha-tocopherol on beta-amyloid-(1-42)-induced learning and memory deficits in rats: implication of oxidative stress in beta-amyloid-induced neurotoxicity in vivo.
  6. The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex.
  7. How to cope with Alzheimer's disease?
  8. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry analysis of proteins in human cerebrospinal fluid.
  9. Effects of specific protease inhibitors on amyloid beta-protein 42 secretion.
  10. Modulation of beta-amyloid precursor protein processing by the low density lipoprotein receptor-related protein (LRP). Evidence that LRP contributes to the pathogenesis of Alzheimer's disease.
  11. Abnormal localization of iron regulatory protein in Alzheimer's disease.
  12. Cellular expression and proteolytic processing of presenilin proteins is developmentally regulated during neuronal differentiation.
  13. Utility of the apolipoprotein E genotype in the diagnosis of Alzheimer's disease. Alzheimer's Disease Centers Consortium on Apolipoprotein E and Alzheimer's Disease.
  14. Increased apolipoprotein E mRNA in the hippocampus in Alzheimer disease and in rats after entorhinal cortex lesioning.
  15. Argyrophilic tau-positive twisted and non-twisted tubules in astrocytic processes in brains of Alzheimer-type dementia: an electron microscopical study.