All Comments by Hiroshi Mori

  1. Survival of cultured neurons from amyloid precursor protein knock-out mice against Alzheimer's amyloid-beta toxicity and oxidative stress.
  2. Apolipoprotein E phenotype is not related to late-life depression in a population-based sample.
  3. Cerebrospinal fluid and plasma insulin levels in Alzheimer's disease: relationship to severity of dementia and apolipoprotein E genotype.
  4. Apoptosis decision cascades and neuronal degeneration in Alzheimer's disease.
  5. Impairments in learning and memory accompanied by neurodegeneration in mice transgenic for the carboxyl-terminus of the amyloid precursor protein.
  6. Contrasting role of presenilin-1 and presenilin-2 in neuronal differentiation in vitro.
  7. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity.
  8. Structural analysis of Alzheimer's beta(1-40) amyloid: protofilament assembly of tubular fibrils.
  9. Sialylated human apolipoprotein E (apoEs) is preferentially associated with neuron-enriched cultures from APOE transgenic mice.
  10. Heparin oligosaccharides that pass the blood-brain barrier inhibit beta-amyloid precursor protein secretion and heparin binding to beta-amyloid peptide.
  11. Decreased beta-amyloid1-42 in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease.
  12. Alteration of proteins regulating apoptosis, Bcl-2, Bcl-x, Bax, Bak, Bad, ICH-1 and CPP32, in Alzheimer's disease.
  13. High-throughput quantitative histological analysis of Alzheimer's disease pathology using a confocal digital microscanner.
  14. Protein anatomy: C-tail region of human tau protein as a crucial structural element in Alzheimer's paired helical filament formation in vitro.
  15. Generation of anti-apoptotic presenilin-2 polypeptides by alternative transcription, proteolysis, and caspase-3 cleavage.