All Comments by Hiroshi Mori

  1. Intracellular inositol (1,4,5)-trisphosphate receptor levels are preserved in Alzheimer's disease platelets.
  2. Alzheimer's disease as proteolytic disorders: anabolism and catabolism of beta-amyloid.
  3. Corticobasal ganglionic degeneration and progressive supranuclear palsy presenting with cognitive decline.
  4. Survival of cultured neurons from amyloid precursor protein knock-out mice against Alzheimer's amyloid-beta toxicity and oxidative stress.
  5. Crystal structure of the N-terminal, growth factor-like domain of Alzheimer amyloid precursor protein.
  6. Tau regulates the attachment/detachment but not the speed of motors in microtubule-dependent transport of single vesicles and organelles.
  7. Novel large apolipoprotein E-containing lipoproteins of density 1.006-1.060 g/ml in human cerebrospinal fluid.
  8. Impairments in learning and memory accompanied by neurodegeneration in mice transgenic for the carboxyl-terminus of the amyloid precursor protein.
  9. Contrasting role of presenilin-1 and presenilin-2 in neuronal differentiation in vitro.
  10. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity.
  11. Structural analysis of Alzheimer's beta(1-40) amyloid: protofilament assembly of tubular fibrils.
  12. Sialylated human apolipoprotein E (apoEs) is preferentially associated with neuron-enriched cultures from APOE transgenic mice.
  13. Heparin oligosaccharides that pass the blood-brain barrier inhibit beta-amyloid precursor protein secretion and heparin binding to beta-amyloid peptide.
  14. Decreased beta-amyloid1-42 in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease.
  15. Alteration of proteins regulating apoptosis, Bcl-2, Bcl-x, Bax, Bak, Bad, ICH-1 and CPP32, in Alzheimer's disease.