All Comments by Hiroshi Mori

  1. The Glu318Gly substitution in presenilin 1 is not causally related to Alzheimer disease.
  2. Apolipoprotein E and antioxidants have different mechanisms of inhibiting Alzheimer's beta-amyloid fibril formation in vitro.
  3. Initial results of a genome survey for novel Alzheimer's disease risk genes: association with a locus on the X chromosome.
  4. The amyloid beta protein induces oxidative damage of mitochondrial DNA.
  5. Expression of ced-3 and ced-9 homologs in Alzheimer's disease cerebral cortex.
  6. Structural analysis of Pick's disease-derived and in vitro-assembled tau filaments.
  7. Cis-acting human ApoE tissue expression element is associated with human pattern of intraneuronal ApoE in transgenic mice.
  8. Isolation and characterization of novel presenilin binding protein.
  9. Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes.
  10. Detection of apolipoprotein E/dimeric soluble amyloid beta complexes in Alzheimer's disease brain supernatants.
  11. Predicting the in vitro toxicity of synthetic beta-amyloid (1-40).
  12. Presenilin-1 mutations associated with familial Alzheimer's disease do not disrupt protein transport from the endoplasmic reticulum to the Golgi apparatus.
  13. Altered calcium homeostasis and mitochondrial dysfunction in cortical synaptic compartments of presenilin-1 mutant mice.
  14. Proteolytic fragments of the Alzheimer's disease associated presenilins-1 and -2 are phosphorylated in vivo by distinct cellular mechanisms.
  15. Hemin and related porphyrins inhibit beta-amyloid aggregation.