All Comments by Hiroshi Mori

  1. A novel neurological phenotype in mice lacking mitochondrial manganese superoxide dismutase.
  2. Age-related alteration of PKC, a key enzyme in memory processes: physiological and pathological examples.
  3. Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes.
  4. Recombinant human amyloid precursor-like protein 2 (APLP2) expressed in the yeast Pichia pastoris can stimulate neurite outgrowth.
  5. Association of alpha1-antichymotrypsin polymorphism with cerebral amyloid angiopathy.
  6. Altered calcium homeostasis and mitochondrial dysfunction in cortical synaptic compartments of presenilin-1 mutant mice.
  7. Perlecan binds to the beta-amyloid proteins (A beta) of Alzheimer's disease, accelerates A beta fibril formation, and maintains A beta fibril stability.
  8. Abnormal accumulation of NACP/alpha-synuclein in neurodegenerative disorders.
  9. Estrogens stabilize mitochondrial function and protect neural cells against the pro-apoptotic action of mutant presenilin-1.
  10. Immunoreactivity of presenilin-1 and tau in Alzheimer's disease brain.
  11. Antibody to caspase-cleaved actin detects apoptosis in differentiated neuroblastoma and plaque-associated neurons and microglia in Alzheimer's disease.
  12. Bleomycin hydrolase is associated with risk of sporadic Alzheimer's disease.
  13. Effects of specific protease inhibitors on amyloid beta-protein 42 secretion.
  14. The beta-amyloid precursor protein of Alzheimer's disease enhances neuron viability and modulates neuronal polarity.
  15. Quantifying amyloid beta-peptide (Abeta) aggregation using the Congo red-Abeta (CR-abeta) spectrophotometric assay.