All Comments by Hiroshi Mori

  1. A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome.
  2. High-dose estradiol improves cognition for women with AD: results of a randomized study.
  3. Nordihydroguaiaretic acid potently breaks down pre-formed Alzheimer's beta-amyloid fibrils in vitro.
  4. NACP, a presynaptic protein, immunoreactivity in Lewy bodies in Parkinson's disease.
  5. No hippocampal neuron or synaptic bouton loss in learning-impaired aged beta-amyloid precursor protein-null mice.
  6. Alzheimer's presenilin-1 mutation potentiates inositol 1,4,5-trisphosphate-mediated calcium signaling in Xenopus oocytes.
  7. Stable association of presenilin derivatives and absence of presenilin interactions with APP.
  8. Solution structure of amyloid beta-peptide(1-40) in a water-micelle environment. Is the membrane-spanning domain where we think it is?
  9. Neuronal DNA damage precedes tangle formation and is associated with up-regulation of nitrotyrosine in Alzheimer's disease brain.
  10. Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins.
  11. Increased vulnerability of hippocampal neurons from presenilin-1 mutant knock-in mice to amyloid beta-peptide toxicity: central roles of superoxide production and caspase activation.
  12. Alzheimer disease: quantitative H-1 MR spectroscopic imaging of frontoparietal brain.
  13. Complete genomic screen in late-onset familial Alzheimer's disease.
  14. Heparin-binding properties of the amyloidogenic peptides Abeta and amylin. Dependence on aggregation state and inhibition by Congo red.
  15. Mutation screening in exons 3 and 4 of alpha-synuclein in sporadic Parkinson's and sporadic and familial dementia with Lewy bodies cases.