All Comments by Hiroshi Mori

  1. A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome.
  2. High-dose estradiol improves cognition for women with AD: results of a randomized study.
  3. Nordihydroguaiaretic acid potently breaks down pre-formed Alzheimer's beta-amyloid fibrils in vitro.
  4. NACP, a presynaptic protein, immunoreactivity in Lewy bodies in Parkinson's disease.
  5. Frontotemporal dementia and Parkinsonism linked to chromosome 17: a new group of tauopathies.
  6. Superoxide mediates the cell-death-enhancing action of presenilin-1 mutations.
  7. Presenilin 1 mutations linked to familial Alzheimer's disease increase the intracellular levels of amyloid beta-protein 1-42 and its N-terminally truncated variant(s) which are generated at distinct sites.
  8. Dementia with Lewy bodies.
  9. Amyloid plaques in Guam amyotrophic lateral sclerosis/parkinsonism-dementia complex contain species of A beta similar to those found in the amyloid plaques of Alzheimer's disease and pathological aging.
  10. Amyloid beta-protein toxicity and oxidative stress in Alzheimer's disease.
  11. Interaction of apolipoprotein E epsilon 4 with other genetic and non-genetic risk factors in late onset Alzheimer disease: problems facing the investigator.
  12. Levels of trkA and BDNF mRNA, but not NGF mRNA, fluctuate across the estrous cycle and increase in response to acute hormone replacement.
  13. Mechanism of action of antiinflammatory drugs.
  14. Oligomerization of endogenous and synthetic amyloid beta-protein at nanomolar levels in cell culture and stabilization of monomer by Congo red.
  15. Par-4 is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer disease.