All Comments by Edward Koo

  1. Copernicus revisited: amyloid beta in Alzheimer's disease.
  2. Use of bomb pulse carbon-14 to age senile plaques and neurofibrillary tangles in Alzheimer's disease.
  3. Endoplasmic reticulum stress-induced cysteine protease activation in cortical neurons: effect of an Alzheimer's disease-linked presenilin-1 knock-in mutation.
  4. Absence of cognitive impairment or decline in preclinical Alzheimer's disease.
  5. Calpain-mediated degradation of p35 to p25 in postmortem human and rat brains.
  6. Head circumference and incident Alzheimer's disease: modification by apolipoprotein E.
  7. Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins.
  8. FAD mutations in presenilin-1 or amyloid precursor protein decrease the efficacy of a gamma-secretase inhibitor: evidence for direct involvement of PS1 in the gamma-secretase cleavage complex.
  9. Augmented senile plaque load in aged female beta-amyloid precursor protein-transgenic mice.
  10. Reduced effectiveness of Abeta1-42 immunization in APP transgenic mice with significant amyloid deposition.
  11. Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier.
  12. Receptor-dependent cell stress and amyloid accumulation in systemic amyloidosis.
  13. Gamma-secretase-like cleavages of Notch and beta APP are mutually exclusive in human cells.
  14. Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate.
  15. Beta-secretase processing in the trans-Golgi network preferentially generates truncated amyloid species that accumulate in Alzheimer's disease brain.