All Comments by Edward Koo

  1. Loss of basal forebrain P75(NTR) immunoreactivity in subjects with mild cognitive impairment and Alzheimer's disease.
  2. APP transgenic mice Tg2576 accumulate Abeta peptides that are distinct from the chemically modified and insoluble peptides deposited in Alzheimer's disease senile plaques.
  3. Cortical inflammation in Alzheimer disease but not dementia with Lewy bodies.
  4. A gene trap insertion reveals that amyloid precursor protein expression is a very early event in murine embryogenesis.
  5. Treatment with controlled-release lovastatin decreases serum concentrations of human beta-amyloid (A beta) peptide.
  6. Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc.
  7. Copernicus revisited: amyloid beta in Alzheimer's disease.
  8. Use of bomb pulse carbon-14 to age senile plaques and neurofibrillary tangles in Alzheimer's disease.
  9. Endoplasmic reticulum stress-induced cysteine protease activation in cortical neurons: effect of an Alzheimer's disease-linked presenilin-1 knock-in mutation.
  10. Absence of cognitive impairment or decline in preclinical Alzheimer's disease.
  11. Calpain-mediated degradation of p35 to p25 in postmortem human and rat brains.
  12. Head circumference and incident Alzheimer's disease: modification by apolipoprotein E.
  13. Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins.
  14. FAD mutations in presenilin-1 or amyloid precursor protein decrease the efficacy of a gamma-secretase inhibitor: evidence for direct involvement of PS1 in the gamma-secretase cleavage complex.
  15. Augmented senile plaque load in aged female beta-amyloid precursor protein-transgenic mice.