All Comments by Edward Koo

  1. Endoplasmic reticulum stress-induced cysteine protease activation in cortical neurons: effect of an Alzheimer's disease-linked presenilin-1 knock-in mutation.
  2. Absence of cognitive impairment or decline in preclinical Alzheimer's disease.
  3. Calpain-mediated degradation of p35 to p25 in postmortem human and rat brains.
  4. Head circumference and incident Alzheimer's disease: modification by apolipoprotein E.
  5. Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins.
  6. FAD mutations in presenilin-1 or amyloid precursor protein decrease the efficacy of a gamma-secretase inhibitor: evidence for direct involvement of PS1 in the gamma-secretase cleavage complex.
  7. Augmented senile plaque load in aged female beta-amyloid precursor protein-transgenic mice.
  8. Reduced effectiveness of Abeta1-42 immunization in APP transgenic mice with significant amyloid deposition.
  9. Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier.
  10. Receptor-dependent cell stress and amyloid accumulation in systemic amyloidosis.
  11. Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate.
  12. Gamma-secretase-like cleavages of Notch and beta APP are mutually exclusive in human cells.
  13. Volumetric MRI study of the caudate nucleus in patients with dementia with Lewy bodies, Alzheimer's disease, and vascular dementia.
  14. Beta-secretase processing in the trans-Golgi network preferentially generates truncated amyloid species that accumulate in Alzheimer's disease brain.
  15. Familial Danish dementia: a novel form of cerebral amyloidosis associated with deposition of both amyloid-Dan and amyloid-beta.