All Comments by Edward Koo

  1. Gamma-secretase-like cleavages of Notch and beta APP are mutually exclusive in human cells.
  2. Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate.
  3. Beta-secretase processing in the trans-Golgi network preferentially generates truncated amyloid species that accumulate in Alzheimer's disease brain.
  4. Volumetric MRI study of the caudate nucleus in patients with dementia with Lewy bodies, Alzheimer's disease, and vascular dementia.
  5. Imaging hippocampal function across the human life span: is memory decline normal or not?
  6. Familial Danish dementia: a novel form of cerebral amyloidosis associated with deposition of both amyloid-Dan and amyloid-beta.
  7. Environmental enrichment slows disease progression in R6/2 Huntington's disease mice.
  8. Preimplantation diagnosis for early-onset Alzheimer disease caused by V717L mutation.
  9. Molecular neuropathology of transgenic mouse models of Down syndrome.
  10. A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing.
  11. Presenilin-1 P264L knock-in mutation: differential effects on abeta production, amyloid deposition, and neuronal vulnerability.
  12. The selective muscarinic M1 agonist AF102B decreases levels of total Abeta in cerebrospinal fluid of patients with Alzheimer's disease.
  13. Nonsteroidal antiinflammatory drugs and the risk of Alzheimer's disease.
  14. Role of the omentum in the treatment of Alzheimer's disease.
  15. Loss of basal forebrain P75(NTR) immunoreactivity in subjects with mild cognitive impairment and Alzheimer's disease.