All Comments by Edward Koo

  1. Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins.
  2. FAD mutations in presenilin-1 or amyloid precursor protein decrease the efficacy of a gamma-secretase inhibitor: evidence for direct involvement of PS1 in the gamma-secretase cleavage complex.
  3. Augmented senile plaque load in aged female beta-amyloid precursor protein-transgenic mice.
  4. Reduced effectiveness of Abeta1-42 immunization in APP transgenic mice with significant amyloid deposition.
  5. Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier.
  6. Receptor-dependent cell stress and amyloid accumulation in systemic amyloidosis.
  7. Gamma-secretase-like cleavages of Notch and beta APP are mutually exclusive in human cells.
  8. Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate.
  9. Beta-secretase processing in the trans-Golgi network preferentially generates truncated amyloid species that accumulate in Alzheimer's disease brain.
  10. Volumetric MRI study of the caudate nucleus in patients with dementia with Lewy bodies, Alzheimer's disease, and vascular dementia.
  11. Imaging hippocampal function across the human life span: is memory decline normal or not?
  12. Familial Danish dementia: a novel form of cerebral amyloidosis associated with deposition of both amyloid-Dan and amyloid-beta.
  13. Environmental enrichment slows disease progression in R6/2 Huntington's disease mice.
  14. Preimplantation diagnosis for early-onset Alzheimer disease caused by V717L mutation.
  15. Molecular neuropathology of transgenic mouse models of Down syndrome.