All Comments by Edward Koo

  1. Alpha-synuclein-immunoreactive deposits in human and animal prion diseases.
  2. Peeling plaque. Researchers remain optimistic about a vaccine against Alzheimer's.
  3. FAD mutant PS-1 gene-targeted mice: increased A beta 42 and A beta deposition without APP overproduction.
  4. Environmental enrichment slows disease progression in R6/2 Huntington's disease mice.
  5. Preimplantation diagnosis for early-onset Alzheimer disease caused by V717L mutation.
  6. A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing.
  7. Molecular neuropathology of transgenic mouse models of Down syndrome.
  8. The selective muscarinic M1 agonist AF102B decreases levels of total Abeta in cerebrospinal fluid of patients with Alzheimer's disease.
  9. Presenilin-1 P264L knock-in mutation: differential effects on abeta production, amyloid deposition, and neuronal vulnerability.
  10. Role of the omentum in the treatment of Alzheimer's disease.
  11. Nonsteroidal antiinflammatory drugs and the risk of Alzheimer's disease.
  12. Loss of basal forebrain P75(NTR) immunoreactivity in subjects with mild cognitive impairment and Alzheimer's disease.
  13. APP transgenic mice Tg2576 accumulate Abeta peptides that are distinct from the chemically modified and insoluble peptides deposited in Alzheimer's disease senile plaques.
  14. Cortical inflammation in Alzheimer disease but not dementia with Lewy bodies.
  15. A gene trap insertion reveals that amyloid precursor protein expression is a very early event in murine embryogenesis.