All Comments by Edward Koo

  1. Alpha-synuclein-immunoreactive deposits in human and animal prion diseases.
  2. Peeling plaque. Researchers remain optimistic about a vaccine against Alzheimer's.
  3. FAD mutant PS-1 gene-targeted mice: increased A beta 42 and A beta deposition without APP overproduction.
  4. Receptor-dependent cell stress and amyloid accumulation in systemic amyloidosis.
  5. Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier.
  6. Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate.
  7. Gamma-secretase-like cleavages of Notch and beta APP are mutually exclusive in human cells.
  8. Volumetric MRI study of the caudate nucleus in patients with dementia with Lewy bodies, Alzheimer's disease, and vascular dementia.
  9. Beta-secretase processing in the trans-Golgi network preferentially generates truncated amyloid species that accumulate in Alzheimer's disease brain.
  10. Imaging hippocampal function across the human life span: is memory decline normal or not?
  11. Familial Danish dementia: a novel form of cerebral amyloidosis associated with deposition of both amyloid-Dan and amyloid-beta.
  12. Environmental enrichment slows disease progression in R6/2 Huntington's disease mice.
  13. Preimplantation diagnosis for early-onset Alzheimer disease caused by V717L mutation.
  14. Molecular neuropathology of transgenic mouse models of Down syndrome.
  15. A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing.