All Comments by John Olney

  1. A new paradigm for neurotoxicity by FAD mutants of betaAPP: a signaling abnormality.
  2. Effects of aging and dementia on the levels of thiobarbituric-acid-reactive products stimulated by L-glutamic acid in human autopsy and biopsy brain tissue.
  3. Isoform-specific modulation by apolipoprotein E of the activities of secreted beta-amyloid precursor protein.
  4. High constitutive NF-kappaB activity mediates resistance to oxidative stress in neuronal cells.
  5. Impairment of glucose and glutamate transport and induction of mitochondrial oxidative stress and dysfunction in synaptosomes by amyloid beta-peptide: role of the lipid peroxidation product 4-hydroxynonenal.
  6. The role of nitric oxide in neurodegeneration. Potential for pharmacological intervention.
  7. Decreased immunosuppressive effect of cortisol on natural killer cytotoxic activity in senile dementia of the Alzheimer type.
  8. Psychotogenicity and N-methyl-D-aspartate receptor antagonism: implications for neuroprotective pharmacotherapy.
  9. Amyloid-beta deposition in Alzheimer transgenic mice is associated with oxidative stress.
  10. Stable complexes involving acetylcholinesterase and amyloid-beta peptide change the biochemical properties of the enzyme and increase the neurotoxicity of Alzheimer's fibrils.
  11. Involvement of neuronal anion exchange proteins in cell death in Alzheimer's disease.
  12. Advanced glycation endproducts in ageing and Alzheimer's disease.
  13. The role of the amyloid protein precursor (APP) in Alzheimer's disease: does the normal function of APP explain the topography of neurodegeneration?
  14. Transcription factor NF-kappaB: friend or foe of neurons?
  15. Presenilins upregulate functional K+ channel currents in mammalian cells.