All Comments by Benjamin Wolozin
- VLDL receptor polymorphism, cognitive impairment, and dementia.
- Hyperphosphorylation induces self-assembly of tau into tangles of paired helical filaments/straight filaments.
- The amyloidogenic pathway of amyloid precursor protein (APP) is independent of its cleavage by caspases.
- Cholesterol-dependent formation of GM1 ganglioside-bound amyloid beta-protein, an endogenous seed for Alzheimer amyloid.
- Cholesterol accumulates in senile plaques of Alzheimer disease patients and in transgenic APP(SW) mice.
- Chronic overexpression of the calcineurin inhibitory gene DSCR1 (Adapt78) is associated with Alzheimer's disease.
- A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome.
- Purification of a pluripotent neural stem cell from the adult mouse brain.
- Tangle-bearing neurons contain more free cholesterol than adjacent tangle-free neurons.
- Disturbed activation of endoplasmic reticulum stress transducers by familial Alzheimer's disease-linked presenilin-1 mutations.
- The amyloid precursor protein (APP)-cytoplasmic fragment generated by gamma-secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture.
- Proteasome inhibition in glyoxal-treated fibroblasts and resistance of glycated glucose-6-phosphate dehydrogenase to 20 S proteasome degradation in vitro.
- Prediction of cognitive decline in normal elderly subjects with 2-[(18)F]fluoro-2-deoxy-D-glucose/poitron-emission tomography (FDG/PET).
- Immunization with a nontoxic/nonfibrillar amyloid-beta homologous peptide reduces Alzheimer's disease-associated pathology in transgenic mice.
- Nicastrin binds to membrane-tethered Notch.