All Comments by Benjamin Wolozin

  1. VLDL receptor polymorphism, cognitive impairment, and dementia.
  2. Hyperphosphorylation induces self-assembly of tau into tangles of paired helical filaments/straight filaments.
  3. The amyloidogenic pathway of amyloid precursor protein (APP) is independent of its cleavage by caspases.
  4. Cholesterol-dependent formation of GM1 ganglioside-bound amyloid beta-protein, an endogenous seed for Alzheimer amyloid.
  5. Cholesterol accumulates in senile plaques of Alzheimer disease patients and in transgenic APP(SW) mice.
  6. Chronic overexpression of the calcineurin inhibitory gene DSCR1 (Adapt78) is associated with Alzheimer's disease.
  7. A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome.
  8. Purification of a pluripotent neural stem cell from the adult mouse brain.
  9. Tangle-bearing neurons contain more free cholesterol than adjacent tangle-free neurons.
  10. Disturbed activation of endoplasmic reticulum stress transducers by familial Alzheimer's disease-linked presenilin-1 mutations.
  11. The amyloid precursor protein (APP)-cytoplasmic fragment generated by gamma-secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture.
  12. Proteasome inhibition in glyoxal-treated fibroblasts and resistance of glycated glucose-6-phosphate dehydrogenase to 20 S proteasome degradation in vitro.
  13. Prediction of cognitive decline in normal elderly subjects with 2-[(18)F]fluoro-2-deoxy-D-glucose/poitron-emission tomography (FDG/PET).
  14. Immunization with a nontoxic/nonfibrillar amyloid-beta homologous peptide reduces Alzheimer's disease-associated pathology in transgenic mice.
  15. Nicastrin binds to membrane-tethered Notch.