All Comments by Benjamin Wolozin

  1. Presenilins are not required for A beta 42 production in the early secretory pathway.
  2. Memapsin 2 (beta-secretase) cytosolic domain binds to the VHS domains of GGA1 and GGA2: implications on the endocytosis mechanism of memapsin 2.
  3. Thrombolysis induces cerebral hemorrhage in a mouse model of cerebral amyloid angiopathy.
  4. Presenilin-2 (PS2) expression up-regulation in a model of retinopathy of prematurity and pathoangiogenesis.
  5. Sensitization of neuronal cells to oxidative stress with mutated human alpha-synuclein.
  6. Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1.
  7. In vivo detection of amyloid plaques in a mouse model of Alzheimer's disease.
  8. The catalytic subunit of telomerase is expressed in developing brain neurons and serves a cell survival-promoting function.
  9. Chaperone-like activity of synucleins.
  10. Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state.
  11. Estrogen replacement therapy for treatment of mild to moderate Alzheimer disease: a randomized controlled trial. Alzheimer's Disease Cooperative Study.
  12. Another Not-Quite-Parkinson's Model
  13. Jun NH2-terminal kinase (JNK) interacting protein 1 (JIP1) binds the cytoplasmic domain of the Alzheimer's beta-amyloid precursor protein (APP).
  14. Distinct FTDP-17 missense mutations in tau produce tau aggregates and other pathological phenotypes in transfected CHO cells.
  15. Increased neuronal damage and apoE immunoreactivity in human apolipoprotein E, E4 isoform-specific, transgenic mice after global cerebral ischaemia.