All Comments by Benjamin Wolozin

  1. Dorfin ubiquitylates mutant SOD1 and prevents mutant SOD1-mediated neurotoxicity.
  2. Presenilins are not required for A beta 42 production in the early secretory pathway.
  3. Memapsin 2 (beta-secretase) cytosolic domain binds to the VHS domains of GGA1 and GGA2: implications on the endocytosis mechanism of memapsin 2.
  4. Thrombolysis induces cerebral hemorrhage in a mouse model of cerebral amyloid angiopathy.
  5. Presenilin-2 (PS2) expression up-regulation in a model of retinopathy of prematurity and pathoangiogenesis.
  6. Sensitization of neuronal cells to oxidative stress with mutated human alpha-synuclein.
  7. Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1.
  8. In vivo detection of amyloid plaques in a mouse model of Alzheimer's disease.
  9. The catalytic subunit of telomerase is expressed in developing brain neurons and serves a cell survival-promoting function.
  10. Chaperone-like activity of synucleins.
  11. Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state.
  12. Estrogen replacement therapy for treatment of mild to moderate Alzheimer disease: a randomized controlled trial. Alzheimer's Disease Cooperative Study.
  13. Another Not-Quite-Parkinson's Model
  14. Jun NH2-terminal kinase (JNK) interacting protein 1 (JIP1) binds the cytoplasmic domain of the Alzheimer's beta-amyloid precursor protein (APP).
  15. Distinct FTDP-17 missense mutations in tau produce tau aggregates and other pathological phenotypes in transfected CHO cells.