Esther Landhuis, Science Writer
Joining Alzforum in 2008 marked Esther Landhuis's third career shift in five years. While working on a Ph.D. in immunology at Harvard, Esther realized that her knack for putting science into words outshone her motivation to find insight within the hundreds of mouse spleens and thymuses she was mashing. So after much soul-searching and the completion of her doctorate in 2003, she entered the UC Santa Cruz Science Communication Program—a nine-month boot camp that turns science practitioners into science writers.
While at UCSC, Esther interned at the city's daily paper, the Santa Cruz Sentinel, and wrote science stories for Stanford News Service and Science magazine's former website on research in aging, SAGE KE. She then did a yearlong internship at the San Jose Mercury News, covering science and health. After several months as a freelance writer (SAGE KE, ScienceNOW, Biomedical Computation Review), the birth of a baby—and another one 18 months later—thrust Esther into her most challenging job thus far: stay-at-home mom. Changing diapers, enduring tantrums and wondering when and how she would ever resume her science writing adventures, she decided the Alzforum opportunity could not have come at a better time.
Esther lives in the San Francisco Bay Area with her husband, who is a physicist-turned-engineering project manager, and their two children—a chatty lass and her fearless brother. She enjoys classical and folk music, shopping on craigslist, watching Boston and Stanford sports teams, and good conversation over tea. Esther considers herself an initiator, organizer, and pursuer of truth.
Amber Dance, Science Writer
Amber Dance joined Alzforum in 2008 soon after completing her scientist-to-writer transition. She majored in biology at Brown University, graduating in 2002, and earned her Ph.D. in 2007 at UC San Diego. In graduate school, she wanted to spend as much time as possible peering through the microscope and taking pretty pictures of cells. That interest led her to projects in intracellular trafficking in mammalian cells and sporulation in bacteria. At UCSD, she received an HHMI Predoctoral Fellowship and also attended the Woods Hole Physiology Course in 2004. In 2006 she received the Biology Department's Excellence in Teaching Award.
But her interests were much broader than a single research project, and she turned to journalism as a way to learn about all kinds of science, and then share her excitement with others. Writing also satisfies the right side of her brain, which demands a creative outlet. At the UC Santa Cruz science communication program she honed her skills in relaying research to readers. At UCSC she received a Cary Lu Memorial Fellowship to support her studies.
Amber interned at the Los Angeles Times and San Jose Mercury News. She also worked at the SLAC National Accelerator Laboratory and for QUEST, a public broadcast program about San Francisco Bay area science. Following a summer 2008 stint at Nature's Washington, DC, office, she began freelancing. She was thrilled to become a part of Alzforum, where she focuses on ALS and related neurodegenerative diseases. Her work is funded by Prize4Life, a nonprofit organization dedicated to accelerating the identification of treatments and a cure for ALS.
Amber lives in the Los Angeles area with her husband, a physicist, and a thoroughly spoiled cat called Nutball. She enjoys hiking as well as homey activities such as cooking and knitting. She also loves to travel, and likes planning the itineraries almost as much as she enjoys the actual trip. To encourage young people with an interest in science, she volunteers as an online "expert" with Science Buddies, answering questions from students working on science fair projects.
Gwen Wong, Drug Database Curator
Gwen Wong has been a working molecular biologist for over 20 years. She has over 9 years' experience in pharmaceutical drug discovery in neurodegenerative diseases, specializing in using transgenic mice for high-throughput in vivo testing of small molecules, proteins, RNAi, gene therapy, and stem cells for Alzheimer disease and amyotrophic lateral sclerosis. Gwen established a high-throughput in vivo pharmacology program for Alzheimer disease drug discovery at Schering-Plough, Kenilworth, New Jersey. This involved extensive in vivo compound screening including acute assays to measure efficacy in γ- and β-secretase inhibition of Aβ as well as toxicity analysis in chronically dosed mice for Alzheimer Disease drug discovery. She also directed in vivo pharmacology at a nonprofit independent research facility ASL Therapy Development Foundation in Cambridge MA. Gwen received her Ph.D. working with Elizabeth Lacy, co-discoverer of the microinjection technique to generate transgenic mice. With Bob Margolskee at Mount Sinai School of Medicine and Roche Institute of Molecular Biology, Gwen generated mice that could not taste bitter substances using gene knockout techniques. Gwen has worked in the molecular biology fields of T cell immunology, taste reception, and neurodegeneration, and her first love in science is mouse molecular genetics and the application of mice in medicine.
Gwen is the curator of Drugs in Clinical Trials for Alzforum. She is also currently curating and writing research and drug development content in a project called Semantic Web Applications in Neuromedicine (SWAN) for Alzforum. It is a welcome and refreshing change to write about exciting science discoveries and developments and not worry about Materials and Methods sections, or to have to dose mice every 8 hours! When not thinking or writing about Alzheimer disease, Gwen is with her kids, her husband Mark Labow of Novartis Pharmaceuticals, in the garden or in the kitchen. Gwen loves to play squash and swim, and is an avid reader of everything.
Don Hatfield, Technology Consultant
Don Hatfield loves to dive headlong into freshly fallen piles of information. Graduated from MIT in History and Mathematics, graduate study in Film and Materials Science. He has publications in the areas of computer systems analysis, computer graphics and programming languages and has played with computers at the IBM Cambridge Scientific Center and Cambridge Graphics/Visualization Center from 1965 to 1992. In 1965 implemented the first relational database within IBM, an interface between a 3D graphics model (3D Sketchpad) and a properties database, and helped the relational database eventually become IBM's relational database product. Founded and was first Chairman of SIGMOD, the ACM Special Interest Group on Management of Data, and worked with members of the MIT Laboratory for Computer Science, then directed by Dr. Joseph Licklider, on the problems of self describing data sets (currently addressed through XMLs) within the Arpanet (later to evolve into the Internet).
At IBM he worked jointly with Dr. Alexander Rich's Lab of the MIT Biology department on computer programs to analyze X-ray diffraction data so as to capture 3D molecular structure, and programs to display the results. The analysis programs were used in the determination of the 3D structure of Transfer RNA, by S.H. Kim, et al. He attempted sporadically to crystallize Ribosomes, with complete lack of success, for an extremely tolerant Dr. Rich. Don Hatfield introduced within IBM the concept of Wysiwyg (what you see is what you get) data handling and programming. He served as internal consultant to IBMs product divisions on document processing, graphic user interfaces and high resolution anti-aliased text and graphics software. He developed first efficient, high resolution algorithm for antialiasing homogeneous-form polynomials (described in Foley, van Dam, et al.) and he designed prototype for Wysiwyg math as a programming language for Image Processing applications, for the ANSI Image Processing API. More recently, he co-founded a company to build Wysiwyg editors for MathML and other XMLs.
Hatfield was part of the Alzheimer Research Forum from the time of its launch, and in 1997 began building the Forum's Antibody Database, and acting as a utility antibody finder for researchers who ask. His other current interests include the following: an XML for antibody data-sheets, the relation between early stages of Alzheimer Disease and neonatal development, MathML extended as a Web programming Language, European History and its Evolution as a Web database; building American Federal Period furniture, and tennis. He and his wife and daughter live in Waltham, Massachusetts.
Sandy Kirley, Research Consultant
Since joining the ARF team in the summer of 2002, Sandy Kirley has been updating the Antibody Database, the Papers of the Week Annotations, as well as responding to "Desperately Seeking Antibodies." She has also been involved in updating the Research Model database.
Sandy graduated from Merrimack College with a degree in biology and chemistry. Her laboratory experience includes protein purification, antibody production, and immunological staining to developing mouse embryo cell lines. She is a coauthor on over 20 journal articles and has done research at the Jimmy Fund and Tufts New England Medical Center. She is currently at Massachusetts General Hospital in the research laboratory of the Urology and Pathology Departments.
She enjoys working on the ARF team which she considers an important contribution to a significant health issue. When not working she spends her time in Andover with her husband, Jim, and their loveable cat, Kleo.
Nico Stanculescu, Event Coordinator
Nico Stanculescu jokingly refers to herself as "Diagonally Parked in a Parallel World" though truthfully admitting she just doesn't know how to parallel park. But with an instinct for networking and making things happen, Nico finds the right people to park cars, play music, cater events or set up exhibit booths. It's allaccording to herin the foundation of win-win and interdependence within a team.
And where did ARF meet Nico? It all happened while working for the Alzheimer's Association in Chicago, where she managed research grants operations. There, she had completely redesigned operational structures and managed the transition from paper to electronic grant application submission and review. From producing events for several hundreds of people to organizing live discussions for the Forum, Nico approaches each project with a can-do attitude and desire to make each project a big success.
Nico grew up in East Africa, lived in Europe for 15 years, and traveled extensively in Asia. She now lives in Chicago and owns a meeting and event planning company, World Events Forum, Inc..
C Knep, Senior Web Developer/Designer
C Knep joined the Alzheimer Research Forum after having worked as a freelance web developer and designer, multimedia developer, the Manager of Web Services of Interland, Inc, and a software localization engineer. He has 18+ years of experience in Information Technologies.
He consults at the highest technical level with the Executive Editor and Executive Producer in determining the overall information systems strategy for the Alzforum website. This position requires identifying the long-term information technology needs of the organization and developing the necessary supporting strategies, including systems development, and integration of all information systems.
The Senior Web Developer is responsible for managing all web development that occurs on the Alzforum website. This includes the supervision of junior developers. Working closely with editors, producers, project managers, science writers, data curators, and Alzheimer researchers, the Senior Web Developer designs, develops, and maintains production-quality, data-driven, front and back-end web applications using the latest technologies including ASP.NET, C#, XML/XSL, HTML, CSS, AJAX, Javascript, T-SQL, ASP Classic, and VBScript. The role of the Senior Web Developer includes the responsibilities of manager, web developer, web designer, database developer, system administrator, and QA tester.