Lifestyle changes to evade dementia, such as healthy eating and exercise, made a strong showing at the Alzheimer’s Association International Conference in Copenhagen, Denmark.
Researchers pumped gel and detergents through rodents to make their entire bodies clear. The new technique will allow scientists to image cells throughout the body.
In mouse models, Aβ aggregates injected into the belly invade the brain, as do prion seeds.
New data strengthens the evidence that dementia risk is dropping in developed countries, possibly due to better education and heart health.
Researchers will have full access to a gargantuan genetic meta-analysis on the newly revamped PDGene database.
A global effort to combat dementia has been conducting a yearlong series of events. Alzforum spoke with Dennis Gillings, who chairs the new World Dementia Council.
A mouse study testing the combined effects of a BACE inhibitor and plaque-clearing antibody builds new support for a combination strategy aimed at reducing Aβ buildup in people.
Could tweaking methodologies improve amyloid diagnosis and tracking?
Researchers have developed a striking new technique that renders the whole body of a rodent clear and accessible to microscopic imaging. By sequentially pumping gels, detergents, and then fluorescent labels throughout the body’s vasculature, researchers can probe deep into all of its organs in subcellular detail. The new method will allow scientists to scrutinize neural circuitry not only within the brain and spinal cord, but throughout the peripheral nervous system. This new imaging access could facilitate detailed tracking of the origins and spread of neurodegenerative diseases.
What comes out when geneticists share data from 15 discrete GWAS studies on 19,000 people with Parkinson’s disease and some 100,000 controls? Twenty-eight genetic variants, some strongly confirmed, others popping up for the first time, plus a trove of data for researchers around the world to analyze. Funded and nudged along by the Michael J. Fox Foundation, the massive collaborative project makes its full results freely available on the all-new PDGene database. Led by Lars Bertram and Christina Lill, this public resource has been outfitted with new features, such as the ability for users to run customized meta-analyses of select data that most interest them, and to add their own lab’s genetic data into on-the-fly meta-analysis.
Held July 12-17 in the Danish capital city of Copenhagen, the Alzheimer's Association International Conference offered no breakthroughs or major surprises, but it did feature numerous incremental steps toward a better grip on the disease. Read here Tom Fagan’s and Gwyneth Zakaib’s accounts of the results of crenezumab's Phase 2 trial and a preclinical combination therapy study. Learn about scientists' attempts to diagnose Alzheimer’s in the eye and about technical improvements in amyloid imaging. Finally, get your update on the global effort to rally against dementia. Over the course of this week, look for more stories on prevention trials, tau PET, and more.
- Ashish Raj on Transparent Bodies Allow Neural Networks to ‘Apparate’
- Michael van Es on Fishing for the ‘Missing Heritability’ of ALS
- Lary Walker on Huntington’s Protein Charged with Trans-synaptic Spread of Pathology
- Ammar Al-Chalabi on Fishing for the ‘Missing Heritability’ of ALS
- Marc Diamond on Huntington’s Protein Charged with Trans-synaptic Spread of Pathology
- Anne-Marie Wills on Heart-Healthy Fatty Acids May Stave Off ALS
- Ammar Al-Chalabi on HDAC6 Is a Bruchpilot Deacetylase that Facilitates Neurotransmitter Release.