Preventing these peripheral phagocytes from creeping into the brain improves memory and ameliorates pathology in mouse models of Alzheimer’s.
Researchers have published RNA expression and processing data for the cerebellum and frontal cortex, and find that C9ORF72-based ALS and sporadic disease differ greatly.
Patients and charities hope people will want to cool off again this summer.
A year after social media campaign, what happened with the money?
A new mass spectrometry analysis provides the most thorough catalog yet of modifications to tau.
Findings suggest a severe blow to the head twists the protein's backbone, which may lead to neurofibrillary tangles.
Clever optical corrections reveal microglia and neurons through the intact mouse cranium.
A C-terminal fragment of APP recruits the protein APPL1 to endosomes, causing the enlarged, overactive vesicles seen early in Alzheimer’s disease.
Neutrophils are the most abundant type of white blood cell, attacking bacteria at sites of inflammation. New research suggests these cells slip into the brain during Alzheimer’s disease. In mouse models, blocking neutrophil entry at early stages of cognitive impairment ameliorated pathology and led to long-lasting improvements in memory. The findings hint that these cells may contribute to tissue damage and pathogenesis.
Last year's ice bucket challenge for amyotrophic lateral sclerosis netted $220 million in donations for ALS charities, and the 2015 challenge is off to a strong start with $100,000 from Major League Baseball. Alzforum looks at how all that money is being spent, on both clinical and basic research as well as patient care.
Researchers have used mass spectrometry to catalog and quantify five types of tau modification in wild-type and transgenic mouse models of AD. While their results suggest little if any difference between normal and plaque-ridden mice, they do reveal previously unknown modifications, and may provide new clues to the protein’s normal function. Other scientists praised the rigor and breadth of the work and its importance for future research. Read the story and extensive commentary.
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