A small trial suggests the drug liraglutide bolsters glucose metabolism in the brains of people with Alzheimer’s, but whether this modifies their disease remains unknown.
Researchers find high levels of certain pesticides in the blood of people with ALS, while in neuronal cultures some of them caused gene expression changes reminiscent of Alzheimer’s.
Nuances in episodic memory can tell if primary progressive aphasia is due to non-tangle types of tau pathology or to plaques and tangles.
Scientists match up PET scans of neurofibrillary tangles against Aβ imaging, CSF measures, and cognitive tests to see how biomarkers change relative to function.
Researchers find essential roles for a signaling pathway involving the kinase complex mTORC1 and the electrical rhythms of REM sleep.
Changing the mix of extracellular ions can put neurons to sleep and swell the brain interstitial fluid for better solute flow.
Knocking down TIA1 rescues tau pathology and toxicity in cells.
PKCα helps Aβ weaken synapses, and rare mutations in some Alzheimer’s families make the enzyme more active.
Man-made chemicals pervade our modern environment and many of them have been implicated as risk factors for neurodegenerative disease. Researchers used blood samples, and gene-expression profiling in neuronal cultures, to pinpoint potentially harmful compounds. They turned up evidence that older pesticides, and a new class of fungicides, may predispose some people to ALS, autism, and Alzheimer’s.
Researchers have tied sleep to clearance of waste products such as excess Aβ. New research suggests this clearance may be driven by a change in the extracellular ion composition, which swells the interstitial fluid. Intriguingly, a change in the ion balance alone can transition brains from wake to sleep states and vice versa. Other recent studies on Virchow-Robin spaces strengthen links between poor sleep, disrupted fluid flow, and neurological disease.
- William Goure, Kalpana Merchant and Grant Krafft on Aβ Oligomers Purified from Human Brain
- Samuel Lockhart on On Multiple Marker Analysis, Tangles Track Best With Functional Decline
- Gil Rabinovici on On Multiple Marker Analysis, Tangles Track Best With Functional Decline
- Laure Saint-Aubert on On Multiple Marker Analysis, Tangles Track Best With Functional Decline
- Roxana Carare and Roy Weller on Sleep and Brain Cleansing—Fresh Insights into Regulation and Disruption
- Berislav Zlokovic on Sleep and Brain Cleansing—Fresh Insights into Regulation and Disruption
- Torik Ayoubi on Pathogenic Presenilin Mutations Generate Aβ43
- Tara Spires-Jones on Stress Granule Protein Entwines and Misfolds Tau
- Daniel Michaelson on APOE ε4 and the associations of seafood and long-chain omega-3 fatty acids with cognitive decline.
- Cecilia Samieri on APOE ε4 and the associations of seafood and long-chain omega-3 fatty acids with cognitive decline.
- Andrea Tenner on Microglia Prune Synapses in a Subtype of Frontotemporal Dementia