Scientists derive a genetic score that predicts the likely age at which a person will develop Alzheimer’s disease.
Daily doses of the antioxidants vitamin E and/or selenium did not reduce incidence of dementia in cognitively normal older men in a randomized, controlled trial.
The toxic Aβ accumulated at postsynapses of a mouse model one month before plaques developed.
A report claims that in the U.K. dementia research grew substantially since 2008, but more gains are needed to find treatments.
Trials enrolling people all at the same Braak stage would need fewer participants to show a drug effect, according to a new analysis.
Route to toxicity converges with RNA binding proteins in membrane-less organelles.
The proposed budget would strike a blow to biomedical research, and science in general.
Tiny infarcts disrupt glymphatic clearance throughout the brain, allowing toxic waste to stick around and inflame surrounding tissue.
Check out the new additions to our research models database. In collaboration with The Michael J. Fox Foundation, Alzforum has incorporated 12 mouse and six rat lines of Parkinson’s disease into our interactive database. The new entries detail the age-dependent progression of pathological and behavioral phenotypes in Lrrk2, Pink1, DJ1, parkin, α-synuclein, and other animal lines. Use our interface to compare and contrast different models and perhaps find just the right one for your experiments. Have feedback? Write to firstname.lastname@example.org or stop by and see us in the exhibitor hall at AD/PD 2017 in Vienna!
Guten Tag! Attending AD/PD 2017 in Vienna next week? We look forward to seeing you. Stop by Alzforum’s booth (#9) to talk with some of our staff and learn more about our news, webinars, databases, and other resources. Early birds may even get a small keepsake. Can’t make it to the conference? As always, our news writers will be on hand to capture highlights of the meeting over the coming weeks.
A new analysis puts solid numbers behind the idea that people with more tau pathology in their brains decline faster on cognitive and clinical measures. The data suggest that trials that enrolled people based on their level of pathology would need fewer participants to detect a drug effect than those enrolling based on clinical status. The approach could in theory make trials more efficient, but it remains to be tested in the real world.
Is one neuron’s intracellular trash another’s stimulating treasure? In a surprising study, researchers report the discovery of proteasomes that exist not in their usual cytoplasmic stomping grounds, but in the plasma membrane of neurons. From there, these proteasomes chomp on intracellular proteins and spit peptides into the extracellular space. The peptides modulate calcium channels, but their identity and broader role in neurobiology remain to be explored.
- Lawrence Rajendran on Infrared Microscopy Reveals Pre-Plaque Formation of β-Sheets by Aβ
- John Cirrito on From Garbage Disposal to Neuromodulation? Membrane Proteasomes Churn Out Stimulating Peptides
- Patrick Fraering on Tetraspanin 6: a pivotal protein of the multiple vesicular body determining exosome release and lysosomal degradation of amyloid precursor protein fragments.
- Samantha Burnham on Alzheimer Disease Signature Neurodegeneration and APOE Genotype in Mild Cognitive Impairment With Suspected Non-Alzheimer Disease Pathophysiology.
- Qian Cai on Transport Breakdown Maroons BACE1 in Synapses, Boosts Aβ
- Roxana Carare and Roy Weller on Mini Strokes Cause Mega Problems for Brain Cleansing
- Thomas Behnisch on From Garbage Disposal to Neuromodulation? Membrane Proteasomes Churn Out Stimulating Peptides
- Reisa Sperling on Selecting Trial Participants Based on Tangle Pathology Might Improve Power
- Felix Schweizer on From Garbage Disposal to Neuromodulation? Membrane Proteasomes Churn Out Stimulating Peptides
- Walter A. Rocca on Bucking Recent Trend, Netherlands Reports Rising Dementia Incidence
- Lei Feng on Bucking Recent Trend, Netherlands Reports Rising Dementia Incidence
- Jiu-Chiuan (J.C.) Chen on A Change in Sleep Habits from Normal to Long: Harbinger of Dementia?
- Giuseppina Tesco on Transport Breakdown Maroons BACE1 in Synapses, Boosts Aβ
- Sudha Seshadri on Bucking Recent Trend, Netherlands Reports Rising Dementia Incidence
- Martin R. Turner on Neurofilament Light Chain as Prognostic Biomarker in ALS
- Kaj Blennow on Neurofilament Light Chain as Prognostic Biomarker in ALS
- Markus Otto on Neurofilament Light Chain as Prognostic Biomarker in ALS
- Suzanne de la Monte on Do ApoE4 and Diabetes Conspire to Spur Cognitive Decline?
- Claudia Almeida on Transport Breakdown Maroons BACE1 in Synapses, Boosts Aβ
- James B. Leverenz on Complement drives glucosylceramide accumulation and tissue inflammation in Gaucher disease.
- Michael Schöll on Multimodal Imaging Ties Tau to Neurodegeneration, and Symptoms