The classic kinase cascade conspires to commit programmed axonal degeneration after injury.
Spinal taps have a bad rap. Are headaches really all that common afterwards, and are there ways to prevent them?
Imaging technique borrowed from cancer care shows that leaks are worse in people who are cognitively impaired.
Upper motor neurons, implicated in many neurodegenerative diseases, are sensitive to both cell stress and hyperexcitability.
All three PET agents demonstrate roughly equivalent abilities to detect brain amyloid, a new analysis finds.
Hollywood turns its attention to a rare form of dementia, giving a personal look at the impact of the disease.
People with Alzheimer’s overexpress the A2A receptor, which suppresses memory in mice.
Mice with amyloid plaques develop runaway neuroinflammation, whereas mice with tau tangles predominantly lose synapses, a gene-expression study reports.
A cellular seal protects the central nervous system from toxins coursing through the blood. This barrier is leaky in people with Alzheimer's disease, but it is unclear where, when, and how this might contribute to neurodegeneration. Using sophisticated magnetic resonance imaging, researchers report in the January 21 Neuron that the barrier begins to fail in the hippocampus of older, cognitively normal people, and more so in people with mild cognitive impairment. This suggests that subtle changes in the integrity of the hippocampal vasculature during normal aging put people at risk for cognitive impairment and may contribute to early stages of dementia associated with AD, say the authors. Senior author Berislav Zlokovic will present this data in a webinar on Tuesday, February 17, at 1 p.m. U.S. Eastern time. Roderick Corriveau and Costantino Iadecola will join for a panel discussion.
Squash an axon and it dies—but wait, not if the neuron has a mutation. By looking for axons that survive crushing, researchers have identified several kinases that regulate axonal disintegration after injury. Might the same kinases might be at work in neurodegenerative diseases? [Image courtesy of Cell, Yang et al.]
Some people develop a nasty headache in the hours and days after a lumbar puncture. How common is this complication, and how can it be prevented? To find out, scientists sifted through records from hundreds of procedures. They found that the amount of fluid drawn, needle size, and perhaps the patient’s posture during the procedure could influence risk.
The MetLife Foundation is now accepting nominations for their 2015 awards. Nominations are due by March 15. New for this year, the foundation will make one major award for medical research, as opposed to two as in previous years, and one award for a promising investigator rather than for promising research. For eligibility and nomination papers, please visit the foundation’s website.
How do the hallmark pathologies of Alzheimer's contribute to disease? According to a new gene-expression analysis of different mouse models, Aβ plaques trigger neuroinflammation but spare synapses, whereas tau tangles lead to synapse loss and degeneration. The results match findings from human studies, and highlight genes that may play crucial roles in each process. The publicly available dataset provides a resource for other researchers.
- Adam Fleisher, Kewei Chen and Eric M. Reiman on Associations Between Biomarkers and Age in the Presenilin 1 E280A Autosomal Dominant Alzheimer Disease Kindred: A Cross-sectional Study.
- Dennis Selkoe and Allen Chen on Lessons from a failed γ-secretase Alzheimer trial.
- Paul Aisen on Lessons from a failed γ-secretase Alzheimer trial.
- Dirk Beher on Lessons from a failed γ-secretase Alzheimer trial.
- Chad Dickey on A Genome-wide Gene-Expression Analysis and Database in Transgenic Mice during Development of Amyloid or Tau Pathology.
- Frances Edwards on A Genome-wide Gene-Expression Analysis and Database in Transgenic Mice during Development of Amyloid or Tau Pathology.
- Gerold Schmitt-Ulms on A Genome-wide Gene-Expression Analysis and Database in Transgenic Mice during Development of Amyloid or Tau Pathology.