Live imaging in mice finds that smooth muscle cells on arterioles exclusively control cerebral blood flow.
Worm study suggests that tipping the balance between progranulin and its granulin fragments might promote frontotemporal dementia.
Better known for lowering cholesterol, statins appear to spur the production of neurotrophins in the brain.
In mice harboring both pathogenic α-synuclein and Aβ, the former puts the brakes on plaque formation by the latter. The model could offer insight into what happens in people with mixed pathology.
Live imaging combined with mathematical modeling suggests that dendritic spines in the hippocampus disappear on the same time schedule as short-term memories fade.
The mice, which lack the ALS- and FTD-linked gene in neurons, indicate that C9ORF72 loss of function alone cannot cause neurodegeneration.
The enzyme complex directly cleaves a protein crucial for survival of B cells, debuting a new type of substrate for the protease.
One author falsified figures, prompting the lab to request a retraction.
Pericytes, the cells that surround capillaries, have been proposed as the main modulators of cerebral blood flow. Now, a new study, using live imaging in transgenic mice, refutes this. Scientists report that only smooth muscle cells surrounding larger arterioles can constrict blood vessels. The data imply that less than 10 percent of brain blood vessels determine total flow, as well as fluctuations due to brain activity. The knowledge may help researchers develop more targeted therapies for brain vascular disorders.
- David Attwell on Smooth Muscle Cells, Not Pericytes, Control Brain Blood Flow
- Roxana Carare and Roy Weller on Smooth Muscle Cells, Not Pericytes, Control Brain Blood Flow
- Michael van Es on ALS Model Worms Sicken Via Innate Immune Pathway
- Brian Freibaum on Scientists Eager to Test ALS Gene Therapy
- Ian McKeith on Alpha-Synuclein Stymies Amyloid Plaques, but Worsens Synaptic Damage
- Jürgen Götz on New Role For PICALM: Flushing Aβ From the Brain
- Hugo Geerts on Advisory Panel Grapples with Combination Therapy