Another paper reports that tau forms liquid droplets, and does so more readily when phosphorylated. What this portends for tangle formation inside of neurons remains to be seen.
Progranulin yields multiple granulins in cells that persist in lysosomes and could be key to preventing FTD.
Progenitors in cortical spheroids, cultured for nearly two years, morph into mature astrocytes, allowing researchers to study this process in vitro.
At AAIC 2017, scientists offered new clues on sleep and AD neuropathology. They identified parts of the brain that may be involved and highlighted the benefits of treating sleep disorders.
Motor symptoms slightly improved in 31 patients taking exenatide for 48 weeks, while the placebo group worsened. The effect persisted three months after treatment stopped.
Injecting a piece of this anti-aging protein days before memory testing improved performance in mice young and old, as well as those that overexpress α-synuclein.
High-throughput sequencing yields surprises. Learn about pathogenic variants in endosomal genes, an algorithm to nab the worst SORL1 mutations, dominant PS1 mutations arising de novo, and tau duplications.
Researchers at AAIC reinforced the idea that tau pathology drives cognitive decline, although amyloid plaques were implicated in semantic memory deficits.
Mutations in the progranulin gene cause a form of frontotemporal dementia, most likely because levels of the protein fall in the central nervous system. How this affects brain function is unknown. A trio of new studies suggests a failure to process progranulins to granulins in lysosomes may be a key.
A consensus report commissioned by The Lancet, and debuted at this year’s AAIC meeting in London, claims that a third of dementia cases could be avoided. “Be ambitious about prevention,” the report urges. Treating midlife hypertension gets top billing among a list of actions that might delay dementia. Beyond prevention, the report lists recommendations that could substantially improve intervention and care for patients right now.
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