Upper motor neurons, implicated in many neurodegenerative diseases, are sensitive to both cell stress and hyperexcitability.
All three PET agents demonstrate roughly equivalent abilities to detect brain amyloid, a new analysis finds.
Hollywood turns its attention to a rare form of dementia, giving a personal look at the impact of the disease.
People with Alzheimer’s overexpress the A2A receptor, which suppresses memory in mice.
Mice with amyloid plaques develop runaway neuroinflammation, whereas mice with tau tangles predominantly lose synapses, a gene-expression study reports.
The addition of a sugar to β-secretase ramps up Aβ production. Could reducing that sweet addition slow progression of Alzheimer's?
Neurons derived from stem cells of people with amyotrophic lateral sclerosis bungle the transmission of electrical signals.
Irritability and depression emerge sooner in AD than in the general population.
The MetLife Foundation is now accepting nominations for their 2015 awards. Nominations are due by March 15. New for this year, the foundation will make one major award for medical research, as opposed to two as in previous years, and one award for a promising investigator rather than for promising research. For eligibility and nomination papers, please visit the foundation’s website.
How do the hallmark pathologies of Alzheimer's contribute to disease? According to a new gene-expression analysis of different mouse models, Aβ plaques trigger neuroinflammation but spare synapses, whereas tau tangles lead to synapse loss and degeneration. The results match findings from human studies, and highlight genes that may play crucial roles in each process. The publicly available dataset provides a resource for other researchers.
One small tweak to a sugar side chain on BACE1 could make all the difference when it comes to Aβ processing, scientists claim. An added monosaccharide appears to slow BACE1’s trek toward the lysosome, keeping it around longer to cut amyloid precursor protein. APP transgenic mice that grew up without the enzyme responsible for this step developed less pathology. Could it provide a new drug target for Alzheimer’s?
- Adam Fleisher, Kewei Chen and Eric M. Reiman on Associations Between Biomarkers and Age in the Presenilin 1 E280A Autosomal Dominant Alzheimer Disease Kindred: A Cross-sectional Study.
- Dennis Selkoe and Allen Chen on Lessons from a failed γ-secretase Alzheimer trial.
- Paul Aisen on Lessons from a failed γ-secretase Alzheimer trial.
- Dirk Beher on Lessons from a failed γ-secretase Alzheimer trial.
- Chad Dickey on A Genome-wide Gene-Expression Analysis and Database in Transgenic Mice during Development of Amyloid or Tau Pathology.
- Frances Edwards on A Genome-wide Gene-Expression Analysis and Database in Transgenic Mice during Development of Amyloid or Tau Pathology.
- Gerold Schmitt-Ulms on A Genome-wide Gene-Expression Analysis and Database in Transgenic Mice during Development of Amyloid or Tau Pathology.