Even as a slew of confounding variables blur results, studies still converge on the benefit of a cognitively stimulating life in old age.
Researchers at AAIC proposed several different measures of brain connectivity that may predict progression to AD.
A new PET ligand uncovers brain areas that are teeming with HDACs and other regions devoid of these enzymes.
Clinical trial design could benefit from new estimates of how slowly amyloid accumulates and how best to detect it at various disease stages.
While the relationship between Alzheimer’s and cardiovascular problems such as hypertension and diabetes remains complicated, a history of stroke is said to double the risk of late-onset AD.
In a validation study, three common software packages produced excessive false positives, but initial stories about previous suspect data might have been overblown.
BACE inhibitors are shaping up; pyroglutamate Aβ antibody clears plaques without ARIA, but immune reaction raises a flag.
Scientists report a way to stop transcription of the repeat expansion, leaving the normal gene alone.
Giving your brain regular workouts—be it reading, jamming on your guitar, or even playing poker—might hedge your bets against dementia, according to a meta-analysis. The analysis scrutinized data from 12 observational studies that examined the effects of late-life cognitive activities on the incidence of dementia and/or Alzheimer’s disease. Researchers concluded that confounding variables such as education and socioeconomic status were unlikely to account for the benefit observed in the studies, although part of the apparent benefit may be due to people slowing down cognitively because they are on the road to dementia. Findings from those studies that examined AD incidence are posted in the AlzRisk database.
Evidence points to epigenetic turmoil in Alzheimer’s disease brains. But what does healthy epigenetic regulation look like, and how does that change with disease and therapy? To find out, scientists have developed a tracer that images a class of HDACs—enzymes that help silence genes for learning and memory. The first data in healthy people suggest these brain HDACs are expressed in a distinct pattern, with lowest expression in the hippocampus and amygdala.
Researchers continue to delve into the time course of Alzheimer’s disease progression, and its earliest signs. At AAIC, they reported an estimate of how slowly amyloid builds up in the brain, and proposed amyloid-based biomarkers that best detect disease progression at early and late preclinical stages. The information may help inform clinical trials and treatment strategies.
Concerns about research reproducibility are leading scientists to question their methods and adopt more rigorous standards. Case in point: A recent validation study of task-based fMRI found that software packages commonly used to analyze the data produce too many false positives. This implies that some fMRI findings in the literature may be erroneous, although initial news stories exaggerated the extent of the problem. Software developers are now revising their programs to correct the issue.
- Philip Landfield on Epigenetic Tracer Uncovers Patterns of Healthy Gene Regulation
- Einar Sigurdsson, Erin Congdon, Ayodeji Asuni and Dov Shamir on Antibody-Mediated Targeting of Tau In Vivo Does Not Require Effector Function and Microglial Engagement.
- Marco Cecchi on Staging of Alzheimer’s, the Second: Neurodegeneration Does Not Equal Tauopathy
- Takaomi Saido on New Ways to Target Aβ and BACE Show Promising Phase 1 Data
- Mark Jenkinson on Software Flaw Casts Doubt on Past Task fMRI Studies
- Prashanthi Vemuri on Software Flaw Casts Doubt on Past Task fMRI Studies
- Jeffrey D. Rothstein on Tackling Mutant C9ORF72 Transcripts at the Source
- Brian Gordon on Improving Tau PET: In Search of Sharper Signals
- Gil Rabinovici on Improving Tau PET: In Search of Sharper Signals
- Patrik Brundin on Aggregation-Prone Gene Expression Signature Mapped in Brain
- Colin Masters on Aggregation-Prone Gene Expression Signature Mapped in Brain
- Bradley Hyman on Aggregation-Prone Gene Expression Signature Mapped in Brain
- Bruno Vellas on Less Salmon, More Plaques? Link Between Omega-3s and Aβ Reinvigorates Fish Oil Debate
- Frederic Calon on Less Salmon, More Plaques? Link Between Omega-3s and Aβ Reinvigorates Fish Oil Debate
- Bruce Kagan on Brain Imaging Suggests Aβ Unleashes the Deadly Side of Tau
- Karen Hsiao Ashe on New APP Antibodies Expose Variation in Mouse Models of AD
- Christopher Rowe on Brain Imaging Suggests Aβ Unleashes the Deadly Side of Tau
- Tsuneya Ikezu on No Special Glasses Needed: Three-Dimensional Views of Tau and Aβ in the Brain
- Ian McKeith on Brain Atrophy Patterns Support Distinct Subtypes of Frontotemporal Dementia
- David M.A. Mann on Brain Atrophy Patterns Support Distinct Subtypes of Frontotemporal Dementia
- Christian Holscher on In First Phase 3 Trial, the Tau Drug LMTM Did Not Work. Period.