Researchers are looking to the eye for a cheap, easy way to detect Alzheimer’s pathology in the brain.
Mutated huntingtin may stow away in synaptic vesicles to sneak from one neuron to another.
At AAIC 2014, crenezumab Phase 2 trial results stirred debate.
Plenty of genetic risk factors for sporadic ALS are still waiting to be found, according to a new meta-analysis of GWAS data.
Heart-healthy foods containing omega-3 fatty acids, like salmon, slash risk of developing ALS by one-third.
The enzyme PARC acts as a survival factor in damaged neurons and cancer cells by targeting a pro-apoptotic protein for destruction.
Novartis Pharmaceuticals Corporation will partner with the Banner Alzheimer's Institute testing experimental preclinical therapies in the upcoming Alzheimer's Prevention Initiative ApoE4 study. The study complements the API ADAD trial.
In fruit flies that model ALS, presynaptic vesicles gather in unusually large clumps, amplifying signaling at the neuromuscular junction. Does this promote disease?
The Alzheimer’s Association International Conference 2014 drew more than 4,000 researchers to the Copenhagen Congress Center, pictured here under the shadow of the Bella Sky Hotel and a massive blade from one of the many wind turbines that stoke the Danes' electrical grid. Clinical trials, brain imaging, biomarkers, and intervention studies powered the meeting program. Data from Phase 2 clinical trials of crenezumab, an anti-Aβ antibody, disappointed, but positive results from a large Finish intervention study raised hope that lifestyle changes can pay dividends toward preventing dementia. The Alzheimer's Prevention Initiative announced a new partnership with Novartis to test if an Aβ vaccine or a BACE inhibitor can slow or prevent sporadic Alzheimer's in people who are genetically predisposed to the disease. Check Alzforum for continuing coverage as we bring you highlights from the meeting, which ran July 12-17 in the Danish capital.
- Lary Walker on Huntington’s Protein Charged with Trans-synaptic Spread of Pathology
- Ammar Al-Chalabi on Fishing for the ‘Missing Heritability’ of ALS
- Marc Diamond on Huntington’s Protein Charged with Trans-synaptic Spread of Pathology
- Anne-Marie Wills on Heart-Healthy Fatty Acids May Stave Off ALS
- Ammar Al-Chalabi on HDAC6 Is a Bruchpilot Deacetylase that Facilitates Neurotransmitter Release.
- Rodney Guttmann on Specific Calpain Inhibition by Calpastatin Prevents Tauopathy and Neurodegeneration and Restores Normal Lifespan in Tau P301L Mice.
- Peter Davies on Specific Calpain Inhibition by Calpastatin Prevents Tauopathy and Neurodegeneration and Restores Normal Lifespan in Tau P301L Mice.