AstraZeneca’s BACE inhibitor AZD3293 moves forward to a Phase 2/3 trial, joining Merck’s MK-8931 as the most advanced current compounds in this class.
Superficial siderosis, a leakage of blood matter onto the outer surface of the cerebral cortex, may be linked to AD and other dementias.
In Fragile X syndrome, mRNA from the mutant FMR1 gene binds to its own DNA to suppress protein expression. Could the same thing happen in other repeat expansion diseases?
Neurons in mice spit out monomeric tau when electrically stimulated, hinting that neural activity may help drive the spread of pathological forms of tau in the brain.
A new initiative in the U.K. will fund research into potential treatments for dementia and neurodegeneration.
Detecting oligomers in the cerebrospinal fluid is no easy feat. The latest test is among the most sensitive yet, but is it useful?
Researchers have identified the striatum as a site of neurogenesis in the adult brain, but not in people with Huntington’s disease.
The FDA has stopped the personal genome sequencing company 23andMe from selling health assessments, saying its tests need validation. What do Alzheimer scientists think?
A vascular disorder called superficial siderosis crops up seven times more often in the brains of people with Alzheimer’s disease than it does in the general population, according to a new study. Serpentine deposits of blood matter lining the surface of the cortex that characterize the disorder may come from the leakage of Aβ-burdened blood vessels. Because superficial siderosis shows up readily on MRI, it could one day serve as a marker of vascular Aβ.
In Fragile X Syndrome—the most common form of inherited mental retardation—a repeating sequence of three nucleotides switches off a key gene. The reason for this genomic silencing has been a mystery, until now. Researchers report that the gene's own messenger RNA is to blame. It sticks to the complementary DNA sequence in the gene and somehow initiates structural changes that turn it off permanently. Experts believe that similar mechanisms may underlie some neurodegenerative diseases.
Adult neurogenesis is not just for the hippocampus anymore. The striatum receives a fresh supply of neurons throughout life, according to a new report. Using carbon-14 to measure the age of cells, researchers discovered that striatal interneurons replenish at a rate of 2.7 percent per year. Curiously, in people with Huntington’s disease, the striatum seems to lack young neurons. Researchers hope this new finding will aid efforts to boost neuronal production after injury or in the context of neurodegeneration.
Clinicians lack a good treatment for the behavioral disruptions that can come with dementia. A new trial indicates that the antidepressant citalopram calms Alzheimer’s patients and makes life easier for their caregivers. But there’s a catch: At the higher dose tested, the drug can slow the heartbeat and put people at risk for cardiac arrhythmia and even death. Researchers agree the drug should be used sparingly when non-pharmaceutical interventions don’t help, and only at lower doses with careful monitoring for side effects.
Top-line results from Prana Biotechnology suggest that the experimental drug PBT2 is safe and tolerated by patients with Huntington’s disease, which causes atrophy of the striatum and other regions of the brain. This therapy is also under investigation as an Alzheimer’s treatment. In the new Phase 2 trial, called Reach2HD, one test of executive function showed statistically significant improvement in patients on the highest dose of the drug. Independent clinical trial specialists cautioned against over-interpreting this finding until all results are published.
- Richard Ransohoff and Haiyan Lu on Transcriptome-based network analysis reveals a spectrum model of human macrophage activation.
- Joana Gil-Mohapel on Neurogenesis in the Striatum of the Adult Human Brain.
- Kaj Blennow, Henrik Zetterberg and Bob Olsson on GSAP Revisited: Does It Really Play a Role in Processing Aβ?
- Meike Vernooij on Prevalence of cortical superficial siderosis in a memory clinic population.
- Kejal Kantarci on Prevalence of cortical superficial siderosis in a memory clinic population.
- Rudy Tanzi on Drug Appears Safe in Huntington’s; Experts Split on Functional Benefit
- Lon Schneider on Drug Appears Safe in Huntington’s; Experts Split on Functional Benefit